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Activities of the Zebrafish Nomenclature Committee
The rapidly expanding wealth of zebrafish genetic and genomic informatio= n makes it essential to give unique and meaningful names to every zebrafish= gene. Good nomenclature practices foster unambiguous communication within = the research community and make electronic data retrieval much easier and m= ore efficient.
The Zebrafish Nomenclature Committee, appointed at a Cold Spring Harbor = meeting several years ago, is alive and well. Our job is to provide guideli= nes and advice for naming genes and mutants. These conventions are based on= input from the zebrafish community and on the rules used for naming human = and mouse genes.
During the past several years, we have participated in the International= Nomenclature Workshops and have published updated guidelines in Trends in = Genetics (Genetic Nomenclature Guide, 1998). The current guidelines are ava= ilable on ZFIN.
The committee continuously reviews zebrafish gene names to consolidate m= ultiple names for the same gene, to assign uniform names to all members of = gene families, and to clarify the relationships between genes in zebrafish = and other vertebrates. These reviews often require BLAST, cluster and mappi= ng analysis. We also work closely with the mouse and human nomenclature com= mittees. The approved name and all other previous names of all published ze= brafish genes are listed on ZFIN.
We encourage all of you to consult the committee before publishing new g= ene names. ZFIN currently supports a mechanism for researchers to reserve n= ames for newly discovered mutants. These names are reviewed by the committe= e to ensure they conform to accepted nomenclature conventions and then give= n a tentative approval that reserves the name until the mutant or gene is p= ublished. To reserve names for genes identified by molecular means, you can= contact the ZFIN nomenclature coordinator (nomenclature@zfin.org)
The mouse and human research communities now require approval from their= respective nomenclature committees before new names can be published. Most= of the major journals support this process by requiring a statement of the= committee's approval for all new names before the manuscript is published.= This helps avoid changing names later because of nomenclature problems. Is= the zebrafish research community ready for this?
Please give us your feedback at: nomenclature@zfin.org
The Committee,
Marc Ekker, Mary Mullins, John Postlethwait, Amy Singer, Monte Westerfield<=
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