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1.

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Chill

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200

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3d

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embryos

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after

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removing

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from

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chorions.

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2.

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Rinse

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in

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0.5%

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chilled

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bleach

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for

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2

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minutes

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and

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then

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in

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zero

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calcium

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Ringer

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for

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2

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minutes.

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3.

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Transfer

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to

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a

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Dounce

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homogenizer

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with

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a

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mini-mum

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of

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liquid

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and

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homogenize

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well.

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4.

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Resuspend

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in

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1

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ml

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L-15

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supplemented

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with

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0.3

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mg/ml

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glutamine,

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50

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U/ml

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penicillin,

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0.05

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mg/ml

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streptomycin

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and

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0.8

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mM

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CaCl2.

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5.

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Store

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at

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-20°C.