...
We annotate such information to allow the users to understand and evaluate the basis on which those orthology assertions were made. If an orthology assertion in ZFIN looks questionable to a user and that user sees that that the assertion was made based only on nucleotide sequence comparison, it may indicate that their skepticism is valid and further investigation is warranted. However, if the orthology assertion is supported by amino acid sequence comparison, nucleotide sequence comparison and conserved genome location (synteny) by numerous sources or publications, it is likely that the orthology assertion is well established and correct. Either of the above scenarios could be wrong, of course, but the information we provide with the evidence codes does allow one to make an initial, informed estimation.
...