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(Comments: This protocol is modified specifically for ChIP-Seq. Many protocols suggested that dynabeads don't don’t need blocking. My own experience is no blocking will lead to non-specific binding and give a relatively stronger background especially you don't don’t have a very clean antibody. Be sure to use non-DNA blocking reagent, otherwise, Solexa will be very sensitive to also pick up your carrier DNA sequence. And your true DNA reading will be much lower.
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Remove sup. (Beads from no-antibody tube could serve as "no Ab" “no Ab” negative control after washing and elution)
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