Postdoctoral position, Özbudak Lab, Cinccinati Children's Hospital Medical Center
The Özbudak Lab (https://www.cincinnatichildrens.org/bio/o/ertugrul-ozbudak ) is looking for a postdoctoral fellow interested in combining interdisciplinary approaches to discover systems-level mechanisms governing spatiotemporal pattern formation during embryonic development.
Embryos develop spatiotemporal patterns by encoding and interpreting biological signals in real time. Despite unavoidable fluctuations in gene expression, embryonic development is robust and reproducible, which necessitates several mechanisms buffering stochastic gene expression. A striking example of robust spatiotemporal patterning is the rhythmic segmentation of somites, which are precursors of the vertebral column. Segmentation of somites is controlled by: 1) oscillatory expression of Hes/Her gene family, known as the vertebrate segmentation clock, 2) short-distance Notch signaling, 3) long-distance Fgf and Wnt signaling gradients, and 4) a network of transcription factors integrating outputs of the segmentation clock and the signaling pathways. Errors in this regulatory cascade result in various birth defects, including congenital scoliosis. We combine single-cell microscopy measurements, time-resolved perturbation experiments, biophysical modeling and computational simulations to decipher the mechanism underlying robust spatiotemporal pattern formation and cell fate determination.
Relevant publications: Nature 2021 589:431-436; Cell Reports 2018 24:66-78; Cell Reports 2018 23:2175-2185.
Interested candidate must have a PhD and have a strong record of accomplishments and experience in:
1- Genetics, developmental biology, microscopy, and image analysis; OR
2- Mathematical and computational modeling, or theoretical physics
We are looking for a colleague who is highly motivated and independent. Please send a cover letter detailing your past research accomplishments and future research goals, and your CV by email to:
Ertugrul M. Ozbudak
Laboratory of Systems Developmental Biology
Division of Developmental Biology
Cincinnati Children's Hospital Medical Center
University of Cincinnati College of Medicine
Email: Ertugrul.Ozbudak@cchmc.org