Postdoctoral Research Fellow, Rességuier Lab, Department of Biosciences, University of Oslo, Oslo, Norway
- Wei-Chia Tseng
About the position
Position as Postdoctoral Research Fellow available at the Department of Biosciences.
Starting date no later than the 1st of September 2025, preferred starting date around the 1st of May/June.
The appointment is a fulltime position and is for a period of three years (10% of which is devoted to required duties, usually in the form of teaching activities).
No one can be appointed for more than one Postdoctoral Research Fellowship at the University of Oslo.
Job description / Project description / Development plan:
Applicants are invited to apply for a 3-year position as Postdoctoral Fellow in Fish Immunology to be based at the Department of Biosciences of the University of Oslo. This role contributes to the ERC-funded starting grant project “Fish-S.H.I.E.L.D.” starting on April 1st 2025, which aims to investigate the fish branchial cavity immune surveillance system and its importance for the fish defense against infectious diseases in aquaculture.
The successful applicant will join Julien Resseguier’s “Spatial Immunology & Nanomedicines” group and become a key member of the Comparative Immunology team at the Department of Biosciences.
The project “Fish-S.H.I.E.L.D.” builds on the recent discovery of a complex lymphoid organization in the fish branchial cavity, which includes the “Amphibranchial Lymphoid Tissues (ALT)” and the “Interbranchial Lymphoid Tissues (ILT)” in the gills, and the Nemausean Lymphoid organ (NELO), revealing the branchial cavity as an important region of the fish immune system.
(https://www.science.org/doi/10.1126/sciadv.adj0101 ) (Frontiers | High-Resolution, 3D Imaging of the Zebrafish Gill-Associated Lymphoid Tissue (GIALT) Reveals a Novel Lymphoid Structure, the Amphibranchial Lymphoid Tissue )
The sustainability of aquaculture, important for our food security, is severely challenged by infectious diseases. Whereas the branchial cavity is particularly relevant for fish health and welfare in aquaculture, much remains to be done to understand its defense mechanisms. The main goal of the project is to characterize the newly discovered branchial cavity immune surveillance system to harness its potential against infectious diseases in aquaculture. The project objective will use the zebrafish model to 1) Characterize the gill lymphoid tissues and tonsil-like organ. 2) Decipher the rules of antigen sampling, 3) Characterize the developmental framework. 4) Study the involvements in immune responses to infection and vaccines. This will then serve as a guide for investigations in Atlantic salmon and other fish species relevant for aquaculture.
The project will involve characterizations of immune functions using infection models and nanotechnologies, immunohistology, transcriptomics, antibody assays, and advanced 3D microscopy. For this, a lightsheet microscope dedicated to the imaging of cleared samples is being acquired, as well as a workstation for VR-assisted image analysis. This represents a unique opportunity in Norway.
We seek a highly motivated postdoctoral fellow that will be primarily involved in the imaging aspects of the project. Tasks will mainly focus on using the zebrafish model to investigate the branchial cavity immune system with an emphasis on immune functions and antigen-sampling. Tasks will also include opportunities to work on experiments with Atlantic salmon.
The main purpose of a postdoctoral fellowship is to provide the candidates with enhanced skills to pursue a scientific top position within or beyond academia. To promote a strategic career path, all postdoctoral research fellows are required to submit a professional development plan no later than one month after commencement of the postdoctoral period.
It is expected that the successful candidate will be able to complete the project in the course of the period of employment.
Qualification requirements:
The Faculty of Mathematics and Natural Sciences has a strategic ambition to be among Europe’s leading communities for research, education and innovation. Candidates for these fellowships will be selected in accordance with this, and expected to be in the upper segment of their class with respect to academic credentials.
Applicants must hold a degree equivalent to a Norwegian doctoral degree in in Fish Immunology, Cell Biology, Molecular Biology, or a related discipline. Doctoral dissertation must be submitted for evaluation by the clos-ing date. Only applicants with an approved doctoral thesis and public defence are eligible for appointment.
Prior experience working with either Zebrafish, Fish immunology (not restricted to zebrafish), or an extensive experience in both Immunology and Imaging.
Documented solid expertise with Confocal Microscopy and/or Lightsheet Microscopy, and Image analysis.
Fluent oral and written communication skills in English.
Desired qualifications:
The following qualifications will also count in the assessment of the applicants: Molecular Biology, Immunology, Fish Biology, Fish Anatomy, Histology methods, Statistics.
Prior experience with the following would also be considered positively: Lightsheet Microscopy, Immunofluorescence, In Situ Hybridization, Fish infection models, Nanoparticles, Sample clearing, Cryosection, Atlantic Salmon, Juveniles/Adult Zebrafish.
A certification to perform animal experiments (e.g. Felasa), good communication/representation skills, and grant writing skills are also desirable but not required.
Personal skills:
Strong motivation
Ability to integrate and collaborate within a cross-disciplinary environment
Ability to work independently and take initiatives
Clarity in communication
Applications must be sent through: https://www.jobbnorge.no/en/available-jobs/job/278595/postdoctoral-research-fellow-in-fish-immunology-microscopy
Closing date for application is April 30th.