Job title: Postdoc Position In The Hehnly Lab Studying The Role Of Cell Division In Tissue Morphogenesis
Institution: Syracuse University/Biology Department, Syracuse, NY
Description: The position of research post doc is available in the Biology Department in the Hehnly lab. Responsibilities include conducting experiments and data analyses, coordinating research efforts, assuming a role of leadership in the lab, training graduate and undergraduate students, and the preparation of manuscripts for publication, and dissemination
of research at national and international conferences.
The Hehnly lab studies the interface between cytoskeletal dynamics and membrane transport and defines how they co-regulate one another to control essential cellular processes such as cell division, fate, and polarity. Strong organizational skills, self-motivation, excellent oral and written communication skills, and the ability to work collaboratively within a diverse, multi-disciplinary research group are essential. Responsibilities include tissue culture, microscopy, supervised and independent research on cilia formation during KV development using zebrafish, mentoring undergraduate and graduate students, and preparing research findings for publication.
Email contact: Judy Freshour, jrfresho@syr.edu
Application link: http://www.sujobopps.com/postings/85014
Lab website: http://www.hehnlylab.com
University website: http://www.syracuse.edu
Job Summary
Dr. Falk's research laboratory at The Children’s Hospital of Philadelphia Research Institute was established in 2006 and is focused in researching the mechanisms underlying disease, and potential novel therapies, for mitochondrial respiratory chain diseases. The laboratory primarily uses human cell, C. elegans (worm) and zebrafish, small animal models, and occasionally mouse models for these purposes.
We have a position open immediately for a research technician to join the group to investigate the therapeutic mechanisms of primary mitochondrial disease through whole-animal behavioral phenotyping and mitochondrial physiology studies, as well as assisting in the evaluation of the efficacy and toxicity of pharmacologic agents in both cell and animal models of primary mitochondrial respiratory chain diseases. This work involves analyses of candidate therapies and high-throughput drug screening, with both academic and pharma partners.
Prior experience is highly desirable in performing translational investigations C. elegans, zebrafish, and/or human cell culture, working with pharmacologic agents, and standard molecular laboratory investigations including gene expression profiling, cell sorting analyses, gene sequencing, and western blot analyses. Experience performing high-throughput drug screening in cells and animal models is strongly preferred. Experience with mitochondrial models or physiology investigations and/or training in pharmacology is highly desirable. The successful applicant will be a team player, work independently but with regular communication with the PI and study team, have strong data analysis skills including in Excel, Prism, ImageJ, and Matlab, excellent organization skills, be a quick learner, be highly attentive to detail, have excellent communication skills, and be able to make a 2 year commitment to this research program.
Preferred applicant:
Prior experience is highly desirable in performing translational investigations in C. elegans (worm), zebrafish, and/or human cell culture, working with pharmacologic agents, microscopy, flow sorting, and standard molecular laboratory investigations including gene expression profiling, cell sorting analyses, gene sequencing, and western blot analyses. Experience performing high-throughput drug screening in cells and animal models is strongly preferred. Experience with mitochondrial models or physiology investigations and/or training in pharmacology is highly desirable. The successful applicant will be a team player, work independently but with regular communication with the PI and study team, have strong data analysis skills including in Excel, Prism, ImageJ, and Matlab, excellent organization skills, be a quick learner, be highly attentive to detail, have excellent communication skills, and be able to make a 2 year commitment to this research
• Bachelor’s degree required
• Minimum 1 year relevant laboratory experience required.
Job Responsibilities
- Performs research procedures on experimental samples with minimal supervision
- Formulates and performs complex lab experiments and analyzes & reports the data
- Performs tasks that require knowledge of advanced techniques and equipment
- Performs advanced calculations and maintains appropriate log and lab notebooks
- Assists with planning specific research protocols and procedures
- Assists in development & troubleshooting of new techniques and ideas
- May be required to modify scientific methods and protocols (in conjunction with PI)
- Checks others results for completeness and accuracy
- May be responsible for training and mentoring new staff
- Assists in the preparing of grants journal articles, poster and oral presentations
- May perform routine and non-routine tests / experiments as needed
Required Education and Experience
Required Education: Associates Degree or active enrollment in a Bachelor’s Degree Program
Required Experience: One (1) year of laboratory experience
Preferred Education, Experience & Cert/Lic
Preferred Education: Bachelor’s Degree
Preferred Experience: Two (2) years of laboratory experience
For further information and application, contact Heather Warman.
Senior Talent Strategist- Research Human Resources ● Talent Acquisition Phone: 267-294-9505
warmanh@chop.edu ● careers.chop.edu
Additional Technical Requirements
All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.
Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.
Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.
VEVRAA Federal Contractor/Seeking priority referrals for protected veterans. Please contact our hiring official with any referrals or questions.
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Talent Acquisition
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The Department of Developmental Biology at Washington University School of Medicine is seeking applicants for a Research Technician II for the Zebrafish Facility.
Washington University in St. Louis is home to one of the largest zebrafish facilities in the world and with robotic feeding and cleaning systems, it is the world’s most modern. The facility allows large-scale, collaborative projects that would not be possible for individual investigators, helping scientists understand human development and disease, from birth defects and cancer to muscle and nerve disorders.
As part of the research services aspect of the Zebrafish Facility, we are looking for a research technician with experience in molecular biology, that will assist with the carrying out of specific experiments that are available as a service to zebrafish investigators (mutant lines generation using genome editing approaches, microinjections, and genotyping) as well as general husbandry duties. The employee will split their time 50/50 with support research services and providing general fish husbandry.
To learn more about this position and to apply please visit: Research Technician II-Developmental Biology – 49071
Or visit: jobs.wustl.edu and search 49071 in Keywords
Reference: Research Assistant Position
Contract: Full-time, 12 months (possibility of yearly renewal)
Location: University of Maryland, College Park MD
Application deadline: December 1st or until filled
Research: Cichlid fishes are some of the most diverse species on the planet. They have rapidly speciated from South America to Africa to India, over quite recent times making them a textbook example of adaptive radiations. Cichlid differ in nearly every aspect of their ecology and physiology and make a wonderful model for understanding phenotypic diversity and rapid speciation. We are fortunate that at the University of Maryland, we have three cichlid groups. This makes for a vibrant community of researchers working to understand the genetic and genomic basis of cichlid diversity underlying their neuroethology, visual communication, and sexual determination.
Along with their other modes of diversity, cichlids have some of the most variable visual sensitivities in all of vertebrates. Species differ in their sensitivities to different parts of the light spectrum. This is the result of species expressing different subsets of the seven available cone opsin genes. This produces species sensitive to either UV to green wavelengths, violet to green wavelengths, or blue to red wavelengths. We have shown that these differences are linked to varying ecologies including the local light environment and foraging styles. We have also used behavioral training experiments to show that cichlids utilize color vision in these important tasks.
We have made some progress in identifying the genetic and genomic mechanisms behind how the seven cone opsin genes are differentially regulated. We have also identified some candidate genes that form part of the opsin regulatory network. This project is a collaboration between the lab of Dr Scott Juntti and Dr Karen Carleton. We are working to make CRISPR mutants to test the role of several of the candidate regulatory genes. This will help us unravel the more complete regulatory network and see how it varies across cichlid diversity.
The position: We are looking for a Research Assistant who can help manage the generation of CRISPR mutants. This will include performing CRISPR injections, and rearing and breeding new cichlid lines. In addition, the research assistant will perform wet lab experiments such as PCR for genotyping and quantitative PCR for quantifying gene expression. They will also be trained in next generation sequencing technologies. The goal will be to contribute to generating data as well as assisting with manuscript preparation.
The ideal candidate:The ideal candidate will have at least a BSc (undergraduate) degree in life sciences. Some molecular biology experience is desirable, including DNA and RNA extraction, gel electrophoresis, genotyping, or quantitative PCR. Strong organizational and record-keeping skills are important. It is key to have some independence but also be willing to work as a member of team of graduate student, post-doctoral and faculty researchers. We are currently also looking for post-doctoral fellows in neuroscience (Juntti lab).
If you are interested in the position, send your CV, cover letter, and list of references to kcarleto@umd.edu.
A grant-supported postdoctoral position aimed at defining pathogenic mechanisms of pediatric disease is available immediately in the Steet lab within the JC Self Research Institute of the Greenwood Genetic Center (GGC). The GGC is a non-profit clinical, diagnostic and research center whose mission is to advance diagnoses and treatment for children with rare genetic diseases. The Research Division is equipped with state-of-the-art technology and equipment, including a new aquaculture facility. This position offers a unique opportunity to engage directly with clinical and molecular geneticists to better understand the genetic basis and molecular pathogenesis of inherited disorders.
We are seeking a highly motivated individual with experience in animal systems who can address complex questions regarding disease pathogenesis. Zebrafish experience and expertise with microscopy is preferred. As many of the projects involve models of Congenital Disorders of Glycosylation, experience in glycobiology is also helpful but not required. The successful candidate will use a combination of cell and animal systems in a highly collaborative environment to investigate disease mechanisms at a molecular and cellular level. Applicants are expected to have a strong record of first author publications from their Ph.D. work, experience with molecular and cell biological techniques and skill in both written and verbal communication. Interested applicants should send their cover letter, resume and list of professional references to Dr. Heather Flanagan-Steet or Dr. Richard Steet.
Email: Dr. Heather Flanagan-Steet, heatherfs@ggc.org
Email: Dr. Richard Steet, rsteet@ggc.org
Email: careers@ggc.org
Fax: (864) 388-1062
The Greenwood Genetic Center is an Equal Opportunity Employer
This BBSRC-funded post-doc will join a team of researchers in Bristol and Manchester investigating how circadian influences impact on inflammatory cells and other cell lineages at sites of tissue damage to regulate collagen deposition and wound repair in zebrafish. Experiments will include live-imaging, molecular biology, FACS and transcriptomic analysis. The work will contribute to a 5-year UKRI-BBSRC-funded sLoLa project entitled “Opportunities to modulate extracellular matrix secretion and assembly for long term health”. The primary “home” for this researcher will be the laboratories of Professor Paul Martin,Professor David Stephens, and Dr. Chrissy Hammond, Bristol, but they will be expected to undertake short-term secondments in other collaborative labs, including that of Professor Qing-Jun Meng in Manchester.
The successful applicant will join a close-knit and enthusiastic research team. The role will involve the day-to-day running of the project, performing a range of research tasks and assisting with training and supervision of postgraduate members of the lab.
A PhD (awarded or imminent) in a biological or biomedical science is essential and the successful candidate should have prior knowledge of tissue repair/regeneration or inflammation and experience of live imaging or working with tissue samples. Previous experience working with zebrafish is highly desirable. The successful applicant will be organised, eager to learn new skills and able to interact with a broad range of colleagues. The funds for this position are available for up to 4 years.
Apply: For job description, further particulars, and to apply: https://tinyurl.com/yy2ys7wy
Closing date: Sunday 6th December 2020
Informal enquiries: Please contact Professor Paul Martin, Paul.Martin@bristol.ac.uk
Martin lab website: http://www.bristol.ac.uk/biochemistry/research/martin-group/
A Scar Free Foundation funded post-doc position is available to join a team of researchers in Bristol investigating how genes associated with scarring (through human cohort studies) might drive good and bad repair outcomes. Experiments will include live-imaging, molecular biology, FACS and transcriptomic/proteomic analysis of inflammatory cells and effector cells including fibroblasts in various zebrafish (and mouse) models of wound repair.
The successful applicant will join the lab of Professor Paul Martin. The role will involve the day-to-day running of the project, performing a range of research tasks, collaborating with other RAs, in particular, a partner post-doc funded on the same grant but working with Professor Nic Timpson who will focus on population health genetic approaches to identify novel “scar genes”. You will also assist with training and supervision of postgraduate members of the lab.
A PhD (awarded or imminent) in a biological or biomedical science is essential and the successful candidate should have prior knowledge of tissue repair/regeneration or inflammation and experience of live imaging or working with tissue samples. Previous experience working with zebrafish is highly desirable but not essential. The successful applicant will be highly organised, eager to learn new skills, ambitious, and able to interact with a broad range of colleagues. The funds for this position are available for up to 5 years.
Apply: For job description, further particulars, and to apply: https://tinyurl.com/y5f35whr
Closing date: Wednesday 2nd December 2020
Leukodystrophy Disease Pathology and Therapeutics
A position for a postdoctoral fellow is available for studies on leukodystrophy disease gene pathophysiology and therapeutics discovery in the Bonkowsky lab (http://medicine.utah.edu/pediatrics/labs/bonkowsky/). The experimental model systems are zebrafish, mouse and human (see paper by Strachan et al., 2017, Human Molecular Genetics). Development and testing of gene therapies are part of the intended goals of the work.
Qualifications: PhD or MD/PhD. Strong background and experience in experimental sciences (such as molecular biology and/or biochemistry) is necessary. Prior experience in genetics, developmental biology, neuroscience, sequencing, programming, and imaging would be advantageous.
Candidates should be ambitious and independent with good communication skills and team mentality; and at least one first-author publication in a well-respected journal.
The lab and setting are an innovative, well- equipped and scientifically stimulating surrounding. Initial employment contract is for one year (renewable) with standard NIH pay scale.
Women and under-represented minorities are especially encouraged to apply. The University of Utah is an Equal Opportunity Employer.
Applications should include a ½ page letter of description of their research interests and career goals, a CV, and the names and contact information of three academic references, and be sent to:
Dr. Josh Bonkowsky
E-Mail: joshua.bonkowsky@hsc.utah.edu
Position: Post Doctoral Research Associate
Salary: £33,797 per annum
Location: University of Bristol
Closing Date: 22nd November
How to apply: https://www.jobs.ac.uk/job/CCD662/research-associate
Applications are invited for a 4-year fully funded post-doctoral research associate position at the University of Bristol. The project is funded by The Scar Free Foundation and will build on previous work published by the PI on epidermal wound healing in adult zebrafish. The project aims to determine the precise roles of a network of four genes during tissue repair and regeneration. Anecdotal clinical evidence suggests these genes may affect scar severity after injury but the cellular and molecular processes involved in this are not understood. This project represents an opportunity to utilise a well-established model and multiple tools within the lab to answer important questions about scarring and tissue regeneration.
The successful applicant will join a close-knit and enthusiastic research team all working on aspects of tissue repair and regeneration. The role will involve the day-to-day running of the project, performing a range of research tasks, writing manuscripts, giving talks and assisting with training and supervision of postgraduate members of the lab.
A PhD in a biological or biomedical science is essential and the successful candidate should have prior knowledge of wound healing and/or tissue repair/regeneration. Experience of live imaging or working with tissue samples is also essential. Previous experience working with zebrafish is highly desirable but not essential. The successful applicant will be highly organised, eager to learn new skills and to interact with a broad range of colleagues.
For informal enquiries please contact Dr Rebecca Richardson, +44 (0)117 3311419, rebecca.richardson@bristol.ac.uk.
Collaborating institutions: SUNY Upstate Medical University and Syracuse University in Syracuse, New York, USA.
An NIH funded postdoctoral position is available to investigate biophysical mechanisms of tissue morphogenesis. A long-standing collaboration between the Amack group at Upstate Medical Universityand the Manning group at Syracuse University brings together mathematical modeling of mechanical properties of tissues with experimental in vivo cell biology in living zebrafish embryos to understand how biophysical forces impact cellular behaviors during morphogenesis. The successful candidate will work in the developmental biology lab of Dr. Jeffrey Amack, and collaborate with other faculty mentors in physics (Dr. Lisa Manning) and cell biology (Dr. Heidi Hehnly) to develop and apply innovative experimental approaches in zebrafish that will include genome engineering, optogenetics, laser ablations, and live imaging of single cells. Candidates who are interested in the position and would like to know more details about the project goals, methods, and extensive collaboration are encouraged to contact us directly to request more information.
The selected candidate will have the opportunity to participate in the postdoctoral development program and other programming offered by the Syracuse BioInspired Institute (https://bioinspired.syr.edu/education/development-program/). Candidates should be highly motivated, have a PhD in life science, and have a strong record of scholarship. Previous experience with microscopy or zebrafish is preferred, but not required. To apply, send a curriculum vitae, a cover letter with a brief statement of research interests and career goals, and the names of 3 references to amackj@upstate.edu. Priority will be given to applications received before December 11, 2020. SUNY Upstate Medical University values diversity and inclusion. Women and under-represented minorities are strongly encouraged to apply.
Interested in neural circuits and synapses? We received a Brain Initiative grant to examine electrical synapses in zebrafish and we are seeking a postdoctoral fellow and a research assistant. See the website for more info on the group (https://www.adammillerlab.com/).
Electrical synapses are the lesser known cousins of chemical synapses, and the coolest part about them is that we know very little about the where, when, and how of their formation – yet we know they are broadly distributed in all brains, both during development and in adulthood. This provides a significant gap as electrical and chemical synapses work in tandem to create neural circuit function and behavior. The work will focus on the generation and examination of transgenic zebrafish to map electrical synapses in the complex vertebrate brain housed in zebrafish. This position is for the Miller lab in Eugene, Oregon, but the grant is collaborative between my group, the Pereda lab in NYC, and the O’Brien group in Texas. Come join a great group of scientists, a great community, and lead the charge on figuring out a new frontier for the vertebrate nervous system!
Successful candidates will have a degree of an appropriate level for the position of application (Ph.D. = PD and B.S. = RA). A published record of accomplishment appropriate to level, and good written and oral communication skills.
Preferred: Experience in model organism biology (zebrafish a plus but not required), cloning, molecular biology of DNA/RNA/protein, microscopy, CRISPR, embryo injections, complex genetics, bioinformatics. Level of experience in these techniques varies depending on level of applicant (RA/PD).
Required: Enthusiasm, excitement to be part of a large multi-lab project, ability to coordinate across labs (dispersed across the U.S.), rigor, organization, excellence and drive.
Eugene, Oregon is an ideal place to work and live, and is an outdoor enthusiast’s paradise. In addition to a mild climate with access to the ocean and mountains, Eugene has affordable housing, bike-friendly streets, and a strong community feel. The University of Oregon is an Equal Opportunity/Affirmative Action Institution committed to cultural diversity and compliance with the Americans with Disabilities Act.
Interested candidates should send a curriculum vitae, bibliography, cover letter with a brief description of research experience and interests, and the names of 3 references (with phone numbers) via e-mail to acmiller@uoregon.edu
We are inviting applications to fill a British Heart Foundation funded post to study cardiac development in zebrafish relating to cilia and cardiac valves. These studies will complement and extend mouse based and human studies. Expertise in: molecular biology including CRSIPR; WISH; immunohistochemistry and resin sectioning; and microscopy are essential. We are looking for a candidate with excellent communication skills, the ability to work independently but also work well within the team.
Full details and application portal are here: https://jobs.ncl.ac.uk/job/Newcastle-Research-AssistantAssociate/627709901/
Informal enquiries to bill.chaudhry@ncl.ac.uk.
Closing date 23rd November 2020.
The following zebrafish-based projects are currently being advertised as part of our BBSRC SWBio DTP programme:
- Neural crest development and endothelin signaling.
- Developmental biology, epigenetics and imprinting.
- Enteric nervous system development and gut microbiome
- Epidermal tissue repair and YAP/TAZ-WBP2
Details of the projects and our 4 year BBSRC-funded PhD program can be found using the above links on FindAPhD.com.
Application deadline is 7th December 2020. Interviews in January, all will be virtual due to the current situation.
Any queries, please feel free to contact me directly.
Best
Robert
Robert N. Kelsh
Professor of Stem Cell and Developmental Biology
Director of Research
Department of Biology & Biochemistry
University of Bath
Bath
BA2 7AY
UK
e-mail: bssrnk@bath.ac.uk
Tel.: +44 1225 383828
ORCiD: 0000-0002-9381-0066
Web-site: http://www.bath.ac.uk/bio-sci/contacts/academics/robert_kelsh/
The Fish Evo Devo Geno Lab (PI: Ingo Braasch, https://www.fishevodevogeno.org/) at Michigan State University is recruiting highly motivated PhD students interested in working on the genomic basis of vertebrate evolution and development to start in Summer/Fall 2021.
The Braasch Lab focuses on genomic and developmental changes that contribute to major transitions during the course of vertebrate evolution and studies evolutionary novelties at the levels of genome structure, gene family evolution, and gene regulation. We combine sequencing and comparative analyses of fish genomes with analyses of molecular evolution and functional genetic and developmental approaches (CRISPR genome editing, transgenics, gene expression analyses, epigenomic profiling) in a variety of model species (zebrafish, spotted gar, medaka, killifish, and others).
Graduate projects fall within the following broader research areas of the group:
1. Functional genomic analyses of zebrafish and other biomedical fish models
Combining genomic sequence comparisons, gene expression analyses and epigenomic profiling, we aim to improve connectivity of teleost biomedical fish models such as zebrafish, medaka, killifishes, etc. to human biology and disease.
2. Genomic and morphological evolution of fishes
How do morphological differences among fish and other vertebrate lineages arise from diversification of gene repertoires? What is the role of gen(om)e duplications and gene losses in generating phenotypic diversity? How do changes in gene regulation contribute to evolutionary novelties and key innovations? We study a number of gene families that are of particular importance for the evolution of the vertebrate body plan, e. g. genes involved in development of the vertebrate-specific neural crest cells.
3. Conquest of land and ‘fish-out-of-water’
We are studying genomic changes and their functional consequences leading to the evolution of tetrapods from fishes and other ‘fish-out-of-water’ scenarios, including the evolutionary loss of genes at the water-to-land transition and the gene regulatory basis of hatching.
We are highly committed to diversity and equity and to foster an inclusive and accessible work environment.
MSU IBIO has a strong research commitment to vertebrate biology with a highly collaborative community of groups working on vertebrate and fish evolution, genomics, development, population genetics, neuroscience, behavior, ecology, and conservation, allowing for vibrant exchange among fields, methods and model systems.
Qualifications:
Applicants should hold a bachelor’s degree in biology, genetics, genomics, molecular biology, bioinformatics, developmental biology, zoology or related fields. Suitable candidates should be enthusiastic about working in an interdisciplinary manner and have a passion for fish/vertebrate biology and evolution. Previous research experience in a relevant area is desired, but not required.
Admission:
Students will be admitted through the MSU IBIO Graduate Program(https://integrativebiology.natsci.msu.edu/graduate-program/) and the MSU Ecology, Evolution, and Behavior (EEB) Program (https://eeb.msu.edu/). Another possible route of admission is through the MSU Genetics and Genome Sciences Graduate Program within the MSU BioMolecular Science Gateway(https://biomolecular.natsci.msu.edu/applicants/how-to-apply/).
Application deadlines for the MSU IBIO and Genetics Graduate Programs are December 1, 2020. Note that GRE scores are not required for application.
Funding:
Financial support is provided through research and teaching assistantships and the PI’s external funding from NSF and NIH. Competitive applicants will be eligible for university fellowships and supported in applying for graduate fellowships from NSF, NIH, and other agencies.
Interested candidates should email Ingo Braasch (braasch@msu.edu) in advance of the application deadlines on December 1.
Please include the following in your email:
1. Brief description of your research interests and how they align with a PhD/Masters in vertebrate Evo-Devo and genomics
2. Curriculum Vitae
3. Names and email contacts of 2-3 references
We are looking forward to your application!
Ingo Braasch
Assistant Professor
Department of Integrative Biology
College of Natural Science
Michigan State University
Twitter: @fishevodevogeno
http://www.fishevodevogeno.org/