Blog from November, 2021

Organizational Unit Overview

East Carolina University (ECU) is a member of the University of North Carolina system, enrolls 28,000 students annually, with over 5,500 pursuing graduate and professional degrees. ECU is classified as a R2-Doctoral/Research-Intensive University and is located in Greenville, NC (pop. 92,000), which lies ~80 miles east of Raleigh and a short distance to the Atlantic coast. Greenville offers a college-town atmosphere, a temperate climate, and outstanding cultural and outdoor recreational opportunities along with affordable costs of living.

The Biology Department is home to more than 1,400 undergraduate majors (BS in Biology and BS in Biochemistry) and instructs more than 17,000 students each academic year. Faculty in the department are committed to providing high-impact training in research to undergraduate, Masters (https://biology.ecu.edu/graduate-studies/) and Doctoral-level (https://idpbbc.ecu.edu/) students. The Department of Biology is broad in its representation of different biological subdisciplines and emphasizes integrative approaches drawing from across the natural sciences. Faculty and students in the Department of Biology have ample opportunity to collaborate with others, including those at East Carolina University’s College of Engineering and Technology, Brody School of Medicine, and School of Dental Medicine.

The department and its shared research facilities (Microscopy, Genomics, and a vivarium) will soon be located in the new Life Science and Biotechnology Building, a gateway to a growing, vibrant downtown district in the coastal region of North Carolina.

The Department of Biology is committed to enriching the lives of students, faculty, and staff by providing a diverse academic community where the exchange of ideas, knowledge and perspectives is an active part of living and learning. The department seeks to create an environment that fosters the recruitment and retention of a diverse student body, faculty, staff and administration and works to increase diversity and access to higher education for groups underrepresented in the sciences by building an environment that welcomes, celebrates, and promotes respect for diversity.

Job Duties              

The Department of Biology (httg://www.ecu.edu/biology) at East Carolina University (http:///www.ecu.edu) seeks to fill a tenure-track faculty position (9-month appointment) at the Assistant Professor level with expertise in Cellular, Molecular, or Developmental Biology to begin
August 2022.

The successful candidate will be expected to establish a vigorous, externally funded research program using cell culture, organoid, or model organisms to address fundamental questions in cellular, molecular or developmental biology. The successful candidate will also actively engage undergraduate and graduate students in research and be expected to teach students effectively in the areas of developmental biology, cell and molecular biology, and/or physiology. The ideal candidate will complement existing faculty strengths in stem cell biology, neurobiology, genetics, biochemistry, and reproductive biology. Successful candidates will become a part of a collegial, interdisciplinary Biology Department and will be expected to participate fully in Departmental, College, and University activities.

Contingent upon available funds.

Minimum Education/Experience       

A Ph.D. in Biology or a closely related field such as, but not limited to, Cellular and Molecular Biology, Physiology, or Anatomy and Cell Biology, two years of post-doctoral or equivalent training, and a scholarly record of achievements. Qualifying degrees must be received at time of consideration from accredited institutions.

Special Instructions to Applicant       

Application materials should be submitted online at www.jobs.ecu.edu using the position number 934011. Applicants must submit the following documents as pdf files: (1) cover letter describing interest in the position; (2) curriculum vitae; (3) detailed statement of teaching philosophy (2 pages max) that includes an outline of the applicant’s vision for incorporating undergraduate and graduate training in the applicant’s research program and creating an inclusive learning environment; (4) statement of research accomplishments and goals (3 pages max); (5) contact information for at least three current references. Applicants are expected to include examples of or potential contributions to diversity, equity, and inclusivity in their cover letter as well as teaching and/or research statements.

The cover letter and/or research statement should include examples of past and potential contributions to diversity through research, graduate student training and/or teaching, including how your personal experiences and professional plans support our commitment to diversity and inclusion. We will ask top candidates to have three reference letters sent to the Search Committee Chair via email within 7 days of notification. Official transcripts and official reference letters are required upon employment.

Inquiries regarding this position may be directed to Dr. Elizabeth Ables (ablese@ecu.edu), Search Committee Co-Chair, or Nick Duncan (duncann17@ecu.edu), Administrative Associate. Review of applications begins on January 10, 2022.

Inquiries regarding the University’s policies and goals regarding diversity may be directed to: Office for Equity and Diversity (https://oed.ecu.edu/).

Additional Instructions to Applicant

In order to be considered for this position, applicants must complete a candidate profile online via the PeopleAdmin system and submit any requested documents. Additionally, applicants that possess the preferred education and experience must also possess the minimum education/experience, if applicable.

Applications must be received in the Department of Human Resources by the closing date of 01/31/2022 to be considered. Please submit an online ECU application for vacancy # 934011 to ECU Human Resources at http://www.jobs.ecu.edu.

ECU is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family-friendly environment in which all faculty and staff can excel and achieve work/life balance.  We encourage qualified applicants from women, minorities, veterans, individuals with a disability, and historically underrepresented groups. All qualified applicants will receive consideration for employment without regard to their race/ethnicity, color, genetic information, national origin, religion, sex, sexual orientation, gender identity, age, disability, political affiliation, or veteran status. 

Visit this job posting at https://ecu.peopleadmin.com/postings/46026

Tooth formation and evolution in zebrafish and other fish species post-doctoral position

The Gibert laboratory within the Dept of Cell and Molecular Biology at the University of Mississippi Medical Center (UMMC, Jackson, MS, USA), (https://www.umc.edu/som/Departments%20and%20Offices/SOM%20Departments/Cell%20and%20Molecular%20Biology/For%20Faculty/Yann%20Gibert.html) (http://zfin.org/action/profile/view/ZDB-LAB-120124-1 ) in collaboration with the Jackman laboratory at Bowdoin College (https://www.bowdoin.edu/profiles/faculty/wjackman/ ) has an exciting opportunity for a PhD levels postdoctoral scientist. A fully funded (minimum NIH scale) postdoctoral position (junior or senior) is available now in tooth morphogenesis and evolution in zebrafish but also other fish species research. The overall goal of the lab is to understand how changes in signaling pathways of gene networks can modify the shape of teeth observed in different fish species feeding on different diets.

We are a highly collaborative laboratory with close collaboration with faculty at UMMC. We are looking for a candidate who can work independently and also collaborate with diverse groups. S/he will have the opportunity to learn and apply a wide set of molecular biology, genetics, pharmacological and microscopic techniques and evolutionary biology techniques for the study of fish formation and evolution in fish. There will be opportunities for development of computational skills of high throughput data. This position offers a rich opportunity to engage in, present and publish research at the frontier of biotech fields related to health, medicine, evo-devo and evolution and will prepare the candidate for the next stage of their career, either in academia or industry.

The successful candidate must have a PhD or equivalent and have a strong interest in either tooth formation, fish evolution or evo-devo exemplified by publication in peer-reviewed journals and past experiences.

The Dept of Cell and Molecular Biology provides outstanding training opportunities and career development at the post-doctoral level in a highly scientifically stimulating and collaborative environment. UMMC has a large campus with multiple schools (graduate, medical, dental, allied-health, nursing, etc...). Our lab is well-equipped, with strong core facilities available. We have a state-of-the art Tecniplast aquatic (built in 2020) with

The Gibert laboratory is currently working on several zebrafish related projects and collaborates with several laboratories in the US and world-wide

Publications related to this project from the Gibert lab and Jackman Lab include the following:

Fraher et al., Mol Cell Endocrinol 2021

Sadier et al., Bioessays 2020

Jackman and Gibert, Subcell Biochem 2020

Gibert et al., Proc Biol Sci 2019

Wyett et al., Endocrine 2018

Kaslin and Gibert, eLS 2018

Fraher et al., Cell Reports 2016

Gibert et al., Proc Biol Sci 2015

Samarut et al., Biochim Biophys Acta 2015

Zhao et al., PLoS Genet 2014

Jackman et al., Evol Dev 2013

Seritrakul et al., FASEB 2012

Gibert et al., FASEB 2010

Jackman and Stock PNAS 2006

Stock et al Development 2006

Gibert et al., Development 2006

Gibert et al., Mol Biol Evol 2005

Jackman et al, Dev Biol 2004

Jackson is located in the heart of the south with the most welcoming people in the country and plenty of outdoor activities available and low cost of living

Our efforts are supported by a recently awarded discovery project (RO1 equivalent) from the National Health and Medical Research council (NHMRC Australia, NIH equivalent), and two NIH grants (including one RO1) and a generous start up package form UMMC as well as internal findings from UMMC and philanthropic foundations

TO APPLY:

Please email CV and reprints of relevant publications to the contact information below. Applicants accepted for initial consideration will be subsequently contacted for letters of reference.

Expected starting date: the position is available now and will be posted until filled

Yann Gibert, PhD

Associate Professor
Department of Cell and Molecular Biology
University of Mississippi Medical Center
Jackson, MS

T: 601 815 1659
e-mail: ygibert@umc.edu

This project aims to characterise some of the fundamental interactions between motor neurons and glial cells (microglia, astrocytes, and oligodendrocytes) in the CNS.

We are looking for an enthusiastic and motivated team member, whose work will involve the generation of transgenic zebrafish, latest CRISPR tools, implementing novel molecular tools, and performing high-end confocal microscopy. Our lab has developed advance molecular techniques to characterise cell-to-cell interactions in the zebrafish spinal cord on a single cell level and in real-time (https://doi.org/10.1007/s00401-018-1875-2; https://doi.org/10.3389/fncel.2015.00321 .

We are looking for a motivated individual with a keen interest in neurodegenerative diseases (we have a focus on MND/ALS), who is eager to learn and work with zebrafish, open to develop novel techniques, and work as part of a larger team.

About us: We are an inclusive team of neuroscientists with a passion for understanding the cellular and molecular drivers in the CNS. We are multicultural, dynamic, and value a healthy work-life balance.

If this sounds like it could be for you, please get in touch.
This position is for a fully funded stipend scholarship for domestic Australian students. Prospective candidates should contact Dr Marco Morsch (https://www.mq.edu.au/research/research-centres-groups-and-facilities/healthy-people/centres/macquarie-university-centre-for-motor-neuron-disease-research/our-people2/morsch-group ) for more information.

Further information can be found here: https://www.mq.edu.au/research/phd-and-research-degrees/scholarships/scholarship-search/data/project-specific-scholarship-investigating-neuron-glia-interactions-in-mndals/

Tenure-track Assistant Professor at UNC Chapel Hill- Neuroscience/Neurobiology

The Department of Biology at the University of North Carolina at Chapel Hill invites applications for a faculty position in Neuroscience at the tenure-track Assistant Professor level. The potential start date is July 1, 2022.

We seek outstanding candidates in any field of basic neuroscience, including (but not limited to) systems, cellular, and behavioral neuroscience. We are especially interested in researchers utilizing experimental model organisms, such as Drosophila, C. elegans, and zebrafish, although those using other experimental organisms or studying neurological disease models are encouraged to apply. The ideal candidate may employ a combination of approaches, including, but not limited to: advanced cellular or molecular imaging, electrophysiology, quantitative analysis of behavior, genetic manipulation of neural circuits or molecules, biochemistry, and computational modeling.

The University of North Carolina at Chapel Hill offers a rich academic environment with extensive opportunities for collaborative research within the institution. As one of the three “points” of The Research Triangle along with Raleigh and Durham, Chapel Hill continually receives accolades for being a top location to live and work due to its exceptional educational, cultural, and recreational opportunities.

https://unc.peopleadmin.com/postings/200504

The Sieger laboratory at the University of Edinburgh is looking for a highly motivated postdoctoral research fellow. Within this project we aim to understand how microglia (the resident macrophages of the brain) contribute to network formation in glioblastoma. We use a combination of tissue culture and zebrafish as a model to understand the interactions of microglia and the developing network during glioblastoma growth. Our aim is to undercover the underlying mechanisms and find ways to inhibit network formation in glioblastoma. You will be part of an international team and lead our studies to understand cellular connections amongst glioblastoma cells and the role of microglia in this process. The post requires extensive experience in cell biology and tissue culture. Experience in using the zebrafish as a model would be an advantage. Furthermore, extensive experience in microglial biology and the required techniques (see job description) would be beneficial. This post is fixed-term for 3 years initially with the option of extension depending on funding renewal.

Application deadline is Dec 2nd 2021. Details can be found at: https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/2551

A fully funded postdoctoral position is available in Dr Michael Harrison’s lab (http://labharrison.com ) in the Cardiovascular Research Institute (https://cvri.weill.cornell.edu/ ), Weill Medical College of Cornell University (WCM) in New York City.

The lab is focused on the coronary vessels that supply the heart with blood1 and lymphatic2 vessels that remove fluid and debris from cardiac tissue. We primarily study zebrafish to understand how the cardiac vasculature system develops and how it supports the highly regenerative response to heart injury.

We utilize live and fixed imaging techniques, zebrafish genetic models, Next-Gen sequencing approaches to dissect the cues driving vascularization and vascular support of heart regeneration.

The scientific environment, resources, and stipend support for this position are excellent. The CVRI is an attractive and dynamic environment with several new labs being established in a state-of-the-art research building.

WCM has a friendly working atmosphere with an excellent infrastructure in one of the most beautiful parts of New York City. Benefits are provided for postdocs (https://tinyurl.com/edtfh28w ) including convenient housing (https://housing.weill.cornell.edu/ ) and employer-sponsored childcare (https://tinyurl.com/9m62ta6h ).

Ph.D. in a biological science or other relevant area is required as is prior or pending publication of original research in peer-reviewed journals. Applicants with experience in molecular biology techniques, transgenesis, microscopy or single cell RNA sequencing experiments are particularly encouraged to apply. Applicants should have the ability to interpret data, summarize findings, and work both independently and collaboratively to develop their projects.

Please send a statement of interest, CV and 3 reference contacts to mrh4003@med.cornell.edu

Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Dev Cell 2015 May 26;33(4):442-54.

Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration. eLife 2019;8:e42762

Job Summary: The Microinjectionist will be responsible for mouse ES cell culture, embryo manipulation and microinjection. Specific job duties are outlined below, and include production of transgenic and CRISPR gene-edited mouse lines, embryo transfer surgeries, sperm and embryo cryopreservation, animal husbandry and assisting with the development of new research protocols.

 

Duties and Responsibilities:

  • Microinjection of plasmid-based transgenes, bacterial artificial chromosomes (BACs) and CRISPR/Cas9 reagents into the pronucleus or cytoplasm of one-cell mouse embryos to create novel transgenic or gene-edited mouse lines.

  • Electroporation of CRISPR gene editing reagents into 1- or 2-cell mouse embryos.

  • Cell culture and microinjection of gene-targeted mouse ES cells to produce mouse germline chimeras for the establishment of novel mouse lines.

  • Embryo transfer surgeries in pseudopregnant mice.

  • Cryopreservation and recovery of mouse sperm and/or embryos.

  • IVF rederivation of novel mouse lines imported into Mount Sinai animal facilities.

  • Animal husbandry necessary for the performance of duties listed above, such as routine monitoring of mice, hormone injections to superovulate donor female mice, tail biopsies to provide samples to investigators for genotype analysis, hormone and buffer preparations, maintenance of specific equipment used in the Core, etc.

  • Assist in the development and/or implementation of new research protocols as they become available in the field of mouse genetics.

  • Occasional weekend work will be required.

  • All duties listed above to be performed in as independent a manner as possible, with minimal supervision of the Director of the Mouse Genetics and Gene Targeting CoRE.

 

We are looking for someone with a minimum of a bachelor's degree and any related experience (such as vertebrate embryo isolation and handling, including zebrafish models) who will be able to join our team and contribute to the expanding services offered by the core. Interested applicants can apply using the following link: https://careers.mountsinai.org/jobs/2701542?lang=en-us

 

The research group

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and metabolism. CMB is located in Biomedicum, a new interdisciplinary research center designed to concentrate much of the experimental research conducted at Karolinska Institutet Campus Solna under one roof to promote collaboration. Biomedicum houses approximately 1,200 researchers and other personnel and allow expensive equipment to be shared and used more effectively.

The main interest in the lab of Olov Andersson is to study how small molecules can promote regeneration of insulin-producing beta-cells and improve metabolic control, as future curative approaches for diabetes. In an ERC-funded lab the successful applicant will use chemical-genetic screening techniques in zebrafish to identify compounds, genes and signalling pathways that can promote β-cell regeneration.

Visit the lab’s website:

https://ki.se/en/cmb/olov-anderssons-group

For examples of how the research can be conducted, please see:

Charbord et al., Nature Metabolism:

https://www.nature.com/articles/s42255-021-00391-x?proof=t

Karampelias et al., Nature Communications:

https://www.nature.com/articles/s41467-021-23673-0

Liu et al., eLife:

https://elifesciences.org/articles/65758

Duties

The present project will span from pharmacology to genetics in zebrafish, as well as translational studies in the mouse and human cell cultures. The studies will include assessing beta-cell neogenesis, proliferation and transdifferentiation, and how such cellular changes affect glycemia.

The zebrafish are amenable to efficient transgenesis and high-resolution imaging. We will make use of these properties to generate transgenic, knock-in and mutant zebrafish for single-cell analysis of phenotypes and lineage tracing.

The successful applicant will have a strong background in cell and molecular biology or biochemistry, and keen interest in using model organisms to study beta-cell regeneration and metabolism.

Funding for the position is available for an initial period of two years.

Entry requirements

We are looking for independent and driven candidates who have at least one first-name publication in a peer-reviewed journal. A documented ability to independently carry out experimental research projects is required, as are good communication skills in spoken and written English.

The successful applicants may have experience in one or several of the following techniques/models:

  1. Molecular, cellular and biochemical techniques, e.g. cloning, qPCR, Western blot and immunohistochemistry

  2. Drug screening

  3. Bioinformatics

  4. Metabolism/diabetes research in mouse models

  5. Organoid cultures

  6. Zebrafish as a model system

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Stockholm

Application process

Contact Olov Andersson for any information by email, olov.andersson@ki.se