Zebrafish Facility Support Technician
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/4557
Apply via online form. Listing will close in 2 weeks.
The MRC Human Genetics Unit (HGU) is seeking to appoint a Zebrafish Facility Support Technician to carry out day-to-day care within the MRC HGU zebrafish facility. The postholder will work with another Facility Technician and the Facility Manager to ensure the effective management and welfare of the fish facility in compliance with Home Office legislation. The postholder will interact daily with the researchers who use the facility and should be motivated to provide support and assistance.
Candidates should have excellent attention to detail and a careful approach. The facility is run by a small team of 3 who work flexibly to support each other. Candidates should be able to organise their own daily schedule and work independently, following guidance from the Facility Manager.
The main responsibilities of this post will be the daily feeding of the fish, including harvesting live food (brine shrimp), and maintaining a high standard of cleanliness in the facility. Ensuring high standards of animal welfare is an integral part of working in the facility. Experience of working with animals, particularly fish, to UK Animal Husbandry standards is desirable. Animal welfare is our highest priority, closely followed by providing an excellent service to the IGC researchers.
A fully funded PhD position (including a generous PhD stipend and University fees for 3 years) is available in the Hall laboratory in the department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, New Zealand. This PhD project is part of a larger government-funded project exploring circadian rhythms in immune cell activity.
The immune response to bacterial infection exhibits circadian rhythmicity, often with enhanced bacterial clearance during the early active phase. This clever adaptation likely evolved to synchronize elevated antibacterial responses with the increased threat of certain infections when active. Circadian rhythms are controlled at the molecular level by a highly conserved set of clock genes that are believed to operate in all cells of the body to regulate oscillations in specific functions throughout the day.
We have previously shown that larval zebrafish demonstrate a conserved circadian-gated host response to infection, with enhanced survival and bacterial clearance when infected during the light/active phase. This PhD project will exploit the optical transparency and genetic tractability of the zebrafish model system to unravel the cell-autonomous contributions of specific clock genes within neutrophils and macrophages during this circadian-gated antibacterial response.
To apply for more information please contact Chris Hall (__ c.hall@auckland.ac.nz__).
The Unit on Developmental Signaling (UDS) seeks candidates for a postdoc position at the NIH campus near Washington, D.C. The postdoc will investigate fundamental questions in developmental biology using cutting-edge molecular optogenetics and quantitative imaging approaches.
The UDS was established July 2021 at the Eunice Kennedy Shriver National Institute of Childhood Health and Human Development (NICHD). We seek to understand how embryonic cells decode signaling to create the diverse cell types needed in healthy adults. We use zebrafish embryos as a vertebrate research model to study in vivo how cells respond to signaling levels, dynamics, and combinations. Toward this goal, we develop molecular optogenetics tools that allow us to manipulate biological processes, including signaling, using light. We apply these tools to the microscopy-friendly zebrafish embryo to investigate fundamental principles guiding embryogenesis. For more information see https://kwrogers-lab.org/.
Candidates with backgrounds in developmental biology, quantitative imaging, and molecular biology are encouraged to apply. Please send your CV, contact info for 2-3 references, and a cover letter describing your expertise and interest in the UDS to katherine.rogers@nih.gov. (Applicants must not have more than 5 years prior postdoc experience.)
A post-doctoral fellow position is available in the laboratory of Dr. Xiaolei Xu, Professor of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine. The successful applicant will join a team that is leveraging powerful zebrafish genetics to model human cardiovascular diseases, to decipher underlying mechanisms, and to develop new therapies. Below please find two representative manuscripts from the lab on doxorubicin-induced cardiotoxicity. Applications are invited from candidates who have a strong background in molecular biology, genetics and/or cardiovascular diseases. Previous experience in animal models of human diseases and/or bioinformatics are favored, but not required. Qualified candidates must be self-motivated and have a strong commitment to basic research. Further enquires (enclosing a CV) regarding the scope and detail of the project should be addressed to: xu.xiaolei@mayo.edu or visit https://www.mayo.edu/research/labs/zebrafish-genetics
Ma X, Zhu P, Ding Y, Zhang H, Qiu Q, Dvornikov AV, Kim M, Wang Y, Lowerison M, Herrmann J, Ekker S, Hsiai TK, Lin X and Xu X. (2020) Retinoid X receptor alpha is a spatiotemporally-specific therapeutic target for doxorubicin-induced cardiomyopathy in adult zebrafish. Science Advances 6(5), eaay2939, PMID: 32064346.[]
Wang Y, Lu X, Wang X, Qiu Q, Zhu P, Ma L, Ma X, Herrmann J, Lin X, Wang W, Xu X. (2021) atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity. Circ Res. Aug 13. PMID: 34384247.
Mayo Clinic College of Medicine is a not-for-profit organization that integrates research with clinical practices and education in multi-campus environment. Mayo offers an attractive benefit package. Salary will be determined by the successful candidate's experience.
Applications, including curriculum vitae and bibliography, summary of past accomplishments, and the names of three references, should be sent to:
Xiaolei Xu, PhD.
Mayo Clinic
Stabile 4-10
200 First Street SW
Rochester, MN USA 55905
Email: xu.xiaolei@mayo.edu
Phone number: 507-284-0685
The Baraban Laboratory at the University of California, San Francisco has an opening for a part-time Research Specialist in the Zebrafish Facility.
Area of Specialization / Responsibilities:
Providing routine care and husbandry of zebrafish including feeding, water exchanges, cleaning, and health monitoring.
Assist in developing and modifying standard operating procedures and practices which promote high-quality, cost-effective operation of the facility.
Interacting with postdoctoral fellows, staff, researchers, and other teams to provide high quality, responsive animal care services.
Monitoring supply and equipment inventory to sustain day-to-day operations.
Maintaining accurate records including room logs, health reports, animal census, and other records as required.
Assist in preparation for all regulatory inspections and site visits including IACUC and AAALAC.
Weekend and Holiday work will be required.
This is an excellent opportunity for a candidate to utilize and expand their knowledge of fish biology and aquaculture while also gaining exposure to various facets of neuroscience research.
Required Qualifications:
Bachelor’s degree in any of the life sciences (e.g., animal science, biology, microbiology, aquaculture) by the time of hire.
Basic computer skills and a working knowledge of computer programs including Microsoft Outlook, Excel, and Word.
The successful candidate will be self-motivated, have excellent communication and organizational skills, and the ability to provide leadership for effective teamwork.
Applicant’s materials must list (pending) qualifications upon submission.
Preferred Qualifications:
Prior experience with aquatic animals and a basic understanding of system maintenance relating to aquaculture systems is preferred.
The candidate will gain ALAT certification through AALAS.
Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.
Please apply online at https://apptrkr.com/3156678 .
UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
The Henry Lab at the University of Maine is searching for a technician. Please see this site for more information: https://umaine.hiretouch.com/job-details?jobid=75968
The Corey lab at Cleveland Clinic is expanding with two positions available immediately: at either the research technician or post-doctoral level. Lab is focused on the origins of pediatric leukemia or sarcoma using zebrafish CRISPR/transgenic and mammalian cell models. Experience in zebrafish developmental biology or cell biology is required. Send letter and CV to Seth Corey, MD at coreylab@mac.com
Research Technician II/III – Poss and Di Talia Labs at Duke University
Description and Details:
The Poss and Di Talia labs use the zebrafish model system to study the quantitative biology of tissue regeneration. We are hiring a research technician for duties to include molecular biology, generation of transgenic animals, surgery, histology, and imaging. Specialized training will be provided. A bachelor’s degree in the biological sciences is required. Enthusiasm for working with animals is essential. Contact Ken Poss at ken.poss@duke.edu or Stefano Di Talia at stefano.ditalia@duke.edu.
Technical duties include:
Breeding, husbandry, and surgeries using model system zebrafish.
Molecular biology including making DNA constructs.
Generation of mutant or transgenic animals by microinjection.
Determine and set up instruments, material and apparatus and operate laboratory equipment required for specific tests.
Prepare chemicals, reagents and solutions.
Obtain, prepare, mount and stain tissue for microscopic examination.
Compile, analyze, document and draw conclusions from experimental results.
Review laboratory methods manual, scientific journals, abstracts and other literature for information applicable to research experiments.
Assist in training new personnel.
Qualifications:
Research Technician II:
Work requires a bachelor's degree in botany, biology, zoology, psychology or other directly related scientific field. No experience is required above education requirement.
Research Technician III:
Work requires skills acquired through the completion of a bachelor's degree in botany, biology, zoology, psychology or other science related scientific field program. Two years of research experience is required. A related master's OR AN EQUIVALENT COMBINATION OF RELEVANT EDUCATION AND/OR EXPERIENCE degree may offset required years of experience on a 1:1 basis, e.g., a two year master's degree in lieu of two years of experience.
To Apply:
· Contact Ken Poss at ken.poss@duke.edu or Stefano Di Talia at stefano.ditalia@duke.edu.
Postdoctoral position
The zebrafish research group of Prof. Anna Jazwinska
at the Department of Biology, University of Fribourg, Switzerland
“Heart and muscle regeneration in zebrafish”
Injuries to human organs, such as the limbs and the heart, result in persistent pathologic conditions. By contrast, zebrafish can naturally reconstitute parts of their fins, the heart and skeletal muscle. The project will address the following questions: Which biological mechanisms guide the remaining cells through the regeneration process? Do regenerative programs of different organs rely on conserved mechanisms? Can all muscle types efficiently regenerate after injury?
This project will demand the generation of transgenic fish lines, CRISPR/Cas9 system technology, pharmacological approaches, transcriptome analysis, and imaging techniques. A conceptual and molecular understanding of natural regeneration in fish will also contribute to developmental biology.
Profile
We are seeking highly motivated researchers preferentially with experience with animal model organisms and bioinformatics. Candidates must have a good knowledge of the English language. French or German communication skills would be a plus.
The working language in the laboratory is English and all PhD courses are taught in English.
We offer:
· a stimulating, interdisciplinary scientific environment
· state-of-the-art central facilities for proteomic, imaging and bioinformatic analyses
· a competitive Swiss salary
Starting dates:
The project is planned in summer 2022.
Contact
Prof. Anna Jazwinska
http://www3.unifr.ch/bio/en/research/groups-in-alphabetical-order/jazwinska-group.html