Blog from November, 2022

Postdoctoral Position in Evolutionary Developmental Biology of Fish, Rutgers the State University of New Jersey, NJ

The Nakamura lab in Department of Genetics at Rutgers university has an NSF-supported postdoctoral position available. The long-term goal of Nakamura lab is to identify the genetic mechanisms underlying fish diversity and their contribution to the fish-to-tetrapod transition. We are particularly interested in how fish fin skeletons diversified and evolved into tetrapod limbs. To this end, we bridge functional genomics, genetics, and embryology using model and non-model organisms, including zebrafish, skates, and sharks. More information about ongoing research projects can be found on the lab website (http://nakamuralab.com/).

Candidates should have strong research records in any of the following areas: developmental biology, evolutionary biology, genomics, or other relevant fields. Our lab is a highly interdisciplinary environment, therefore, scientific curiosity and strong communication skills are necessary. Experience in zebrafish embryology, high-throughput sequencing, or bioinformatics data analysis is preferred, but not required.

Rutgers University is located in New Brunswick, NJ, which is only 45 minutes away from NYC by train. Many competitive research universities and institutes are in the Northeast area, offering remarkable opportunities for collaboration and research conferences. The Nakamura lab regularly visits the American Museum of Natural History (https://www.amnh.org/ ) and the Marine Biological laboratory (https://www.mbl.edu/ ) for the purpose of analyzing unique specimens and educating students.

Candidates should send a curriculum vitae, brief statement of current research, and contact for three references to nakamura@dls.rutgers.edu(Tetsuya Nakamura).

2 positions as research technicians – exploration of cyanobacteria/microalgae for metabolic diseases

CIIMAR – Interdisciplinary Centre of Marine and Environmental Research

BBE Blue Biotechnology and Ecotoxicology group Matosinhos, Portugal

Deadline: 16 December 2022

Contact: Dr Ralph Urbatzka, rurbatzka@ciimar.up.pt

Job details: https://www2.ciimar.up.pt/pdfs/jobs/edital_2022_103_ts_bioeconomiaazul_DCKhR_.pdf

The selected candidates will join the PRR Vertical Algas project team and BBE Blue Biotechnologyand Ecotoxicology Group. The objective is the exploration of cyanobacteria/microalgae for biotechnological applications, in particular for metabolic diseases. The tasks will include the extraction and fractionation techniques to produce extracts/fractions, analyses of bioactivities using phenotypic screening assays based on cells in vitro and on wildtype and transgenic zebrafish larvae in vivo. Metabolite profiling will be employed for dereplication and prioritization of bioactive fractions. Some bioactive fractions will be further characterized for their molecular modesof actions.

The candidate will also be involved in the tasks of preparing project reports and their deliverables, as well as participating in project meetings, preparing manuscripts and other forms of communicating results. The selected candidate will also participate in laboratory management (orders, inventories) and maintenance of wild type and transgenic zebrafish strains.

Research Assistant I - Genetics Research Lab/Zebrafish

https://jobs.bcm.edu/job/Houston-Research-Assistant-I-Genetics-Research-LabZebrafish-Texa/959226100/

Work Location: Houston, TX

Requisition ID: 13828

Summary

The Research Assistant will provide higher level chemical and procedural support for experimental services provided by the BCM zebrafish core, including molecular biology and experiments using zebrafish. Will perform experiments using zebrafish, document results of experiments, and keep track of experiments and their progress for core directors and core users.

Job Duties

  • Use advanced biochemistry, microscopy, and manipulative procedures on delicate tissue samples

  • Carry out complex independent experimental work (approximately 40% of the time):

    • zebrafish embryo whole mount in situ hybridization

    • in vitro fertilization and cryopreservation of sperm samples

    • molecular assays including recombinant DNA cloning and PCR

    • tissue histology and microscopy

    • data analysis and generating figures

  • Plan and organize administrative operations of the laboratory (40% of the time):

    • oversee lab inventory and supplies

    • maintain lab stock solutions

    • establish procedures for use of laboratory equipment including maintenance and repair

  • Perform zebrafish core colony maintenance (20% of the time):

    • maintain and propagate zebrafish strains

    • collect embryos for experiments

    • perform fin clips and genotyping

  • Lift and move 15 pound objects (zebrafish tanks full of water)

  • Work in a 28 degree Celsius room with high humidity

  • Work with, handle, and euthanize zebrafish; will train to perform these tasks

  • Perform lab skills such as titrating chemicals and preparing laboratory solutions, work proficiently with lab tools and equipment such as pipettes, PCR machines, micro-injection rigs, etc

Minimum Qualifications

  • Bachelor's degree in a Basic Science or a related field.

  • Two years of relevant experience.

Preferred Qualifications

  • Master's degree preferred.

  • Minimum two years' experience working in a biology lab or biomedical research wet lab, classes (eg undergraduate biology laboratory) do not count toward this requirement.

  • Experience performing PCR, nucleic acid purification, and making/diluting laboratory solutions.

  • Basic proficiency with Microsoft Word, Excel and PowerPoint.

  • Experience handling and working with zebrafish, experience with CRISPR mutagenesis, experience cloning plasmid DNA ((using Gateway recombination, Gibson assembly or similar), experience with histology and imaging, proficiency with FileMaker database software.

  • Experience working with zebrafish is preferred but not required; willing to train.

Job title: Postdoc position: Decoding developmental signaling with optogenetics (NICHD, Bethesda, MD)

Institution: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Contact name: Katherine W. Rogers, PhD

Contact email: katherine.rogers@nih.gov

Lab website: https://kwrogers-lab.org/

Institute website: https://www.nichd.nih.gov/

Description: The Unit on Developmental Signaling (UDS) seeks candidates for a postdoc position at the NIH Bethesda campus near Washington, D.C. The postdoc will investigate fundamental questions in developmental biology using cutting-edge molecular optogenetics and quantitative imaging approaches.

The UDS was established July 2021 at the Eunice Kennedy Shriver National Institute of Childhood Health and Human Development (NICHD). We seek to understand how embryonic cells decode signaling to create the diverse cell types needed in healthy adults. We use zebrafish embryos as a vertebrate research model to study in vivo how cells respond to signaling levels, dynamics, and combinations. Toward this goal, we develop molecular optogenetics tools that allow us to manipulate biological processes, including signaling, using light. We apply these tools to the microscopy-friendly zebrafish embryo to investigate fundamental principles guiding embryogenesis. For more information see https://kwrogers-lab.org/.

Candidates with backgrounds in developmental biology, quantitative imaging, or molecular biology are encouraged to apply. Please send your CV, contact info for 2-3 references, and a cover letter describing your expertise and interest in the UDS to katherine.rogers@nih.gov. (Applicants must not have more than 5 years prior postdoc experience.)

https://wvu.taleo.net/careersection/wvu_research/jobdetail.ftl?job=21157&lang=en#.Y4UVLTgM5-Q.link

West Virginia University Research Corporation is currently accepting applications for a Lab Tech for the Department of Biology in the Eberly College of Arts and Sciences.

About the Opportunity

The individual to fill this position will perform experiments and gather and analyze data in a developmental neurobiology lab. They will perform overall lab management duties with input and oversight of the lab supervisor (PI) and be responsible for maintaining and managing a small (~400 tank) zebrafish satellite facility that is essential to our research. The individual will help recruit, interview, hire, and train individuals, including students, who work in the lab as well. 

At WVU Research Corporation, we strongly believe in work-life balance and keeping time for things we love outside our work. WVU Research Corporation offers a comprehensive benefits package with a variety of options to suit your needs:

  • 13 paid holidays (staff holiday calendar)

  • PTO

  • 403(b) retirement savings with a fully vested 3% employee contribution match, (Employees have the option of contributing an additional 1-3% of their earnings to the plan, which is also matched by the WVURC)

  • A range of health insurance and various other benefits

  • Dependent Education Scholarship

  • WVU Perks

What You'll Do

Zebrafish Facility:

  • Raising and maintaining wild type, mutant, and transgenic zebrafish lines and in vitro fertilization.

  • Shipping and receiving zebrafish lines and laboratory equipment and reagents as needed.

  • Generating mutant and transgenic zebrafish by microinjection of synthesized DNA and RNA, raising multiple generations, and screening.

  • Assuring that the fish facility and laboratory are clean and organized per required safety and operating procedures.

  • Daily zebrafish health and water quality checks, daily feedings of live and dry foods, culturing live foods (rotifers and hatch fry), maintaining detailed fish facility records.

  • Perform fin biopsies of zebrafish for genotyping and line maintenance.

  • Ability to lift and move fish tanks containing up to 6L of water and occasionally transporting lab reagents up to 50 lbs.

  • Respond to and alert supervisor to all fish facility emergencies including those occurring after business hours, on weekends, and on holidays.

General Lab Duties and Experiments:

  • Recommending and implementing with permission improvements to operating conditions or procedures based on evidence and experience. 

  • Stay current on best practices for managing a small university laboratory and zebrafish facility through reading published books and journal articles and attend relevant conferences, workshops, and webinars in these topics.

  • Abiding by, knowing, developing, and teaching all animal care and use practices and lab safety standards of the university and our funding sources.

  • Prepare laboratory and fish facility stock solutions.

  • Ensure lab and fish facility equipment is maintained, operating, and calibrated as needed.

  • Order lab and fish facility supplies as needed and maintain records of all orders.

  • Maintaining excellent experimental records, analyzing data, and reporting to and discussing experimental outcomes and lab and fish. facility management issues with the principal investigator of the lab and more formally at lab meetings.

Personnel Management:

  • Ability to maintain good working relationships with supervisor, other lab members, and faculty and staff in the WVU biology department.

  • Assist lab supervisor in recruiting, evaluating, hiring, and training other lab personnel, including students, in zebrafish care and in standard lab techniques and practices.

 

Qualifications

 

  • Bachelor's in a relevant field (i.e. biology, marine biology, biochemistry, molecular and cellular biology, genetics).  Master's degree preferred.

  • A minimum of one (1) year of experience involving:

    • Research or teaching lab experience.

    • Experience with zebrafish or handling and caring of other aquatic organisms is highly desired. 

    • Basic math and statistics.

    • Introductory chemistry (i.e. lab math for stock solution and other preparations).

  • Knowledge of, willingness to learn and/or experience performing the following laboratory techniques: 

    • DNA, RNA and protein extraction from fish tissue and cells, FACS, PCR, RT-PCR, qPCR, western blotting, molecular cloning, competent cell and agar plate preparation, gel electrophoresis. 

    • Gene/Protein expression analysis: in situ hybridization, immunohistochemistry, RNAseq.

    • Microscopy: light and fluorescence dissecting and compound scopes, confocal imaging, 2-photon imaging.

  • Computer (PC) skills: biological databases and bioinformatics resources, Microsoft Office or equivalent (Excel, Word, Power. Point), PubMed, File Maker Pro or equivalent, other lab database software, image acquisition and processing software.

  • Demonstrated ability to perform biological experiments and analyze data.

  • Demonstrated ability to communicate effectively, ask questions, seek out new knowledge, troubleshoot, and navigate. laboratory issues in an honest, open, and efficient fashion.

  • Demonstrated ability to meet deadlines and manage multiple ongoing tasks successfully at the same time.

  • Demonstrated ability of detailed record keeping.

  • Ability to perform with full professionalism and integrity.

 

Requirements 

  • Must be able to lift between 40-50 lbs (i.e. 5 gallon bucket of water).

  • Must be able to work in a warm (77-78 degree F) and humid (~30-60%) environment.

  • Must be OK handling fish tanks and submerging hands to elbows in water to clean them with PPE.

  • Multitasking and tracking and performing lab duties accurately, correctly, and efficiently is essential, we are a high-pressure research lab environment that needs to generate data for publications and to gain funding; we are subject to many university and federal rules about the work that we perform and have high standards in place for this.

 

About Research Corporation 

The WVURC was created as a not-for-profit corporation in 1985 to support research (R1) at West Virginia University. We provide evaluation, development, patenting, management, and marketing services for inventions of the faculty, staff and students of the University.

The WVURC receives and administers funds awarded by external agencies for research and other activities and is responsible for helping protect intellectual property through patents, copyrights and licensing agreements for start-up companies based on University research.

Creating an inclusive, engaged, and dynamic environment is core to WVURC’s mission. We welcome candidates who can contribute a range of ideas, approaches and experiences.

West Virginia University Research Corporation is proud to be an Equal Opportunity employer. We value diversity among its employees and invites applications from all qualified applicants regardless of race, ethnicity, color, religion, gender identity, sexual orientation, age, nationality, genetics, disability, or Veteran status.

PostDoc position (junior researcher) – exploration of cyanobacteria/microalgae for metabolic diseases


CIIMAR – Interdisciplinary Centre of Marine and Environmental Research
Matosinhos, Portugal
BBE Blue Biotechnology and Ecotoxicology group

Deadline: 13 December 2022

Contact: Dr Ralph Urbatzka, rurbatzka@ciimar.up.pt

Job details: https://www2.ciimar.up.pt/pdfs/jobs/edital_2022_104_ij_bioeconomiaazul_429xb_.pdf

The selected candidate will join the PRR Vertical Algas project team and BBE Blue Biotechnology and Ecotoxicology Group. The objective is the exploration of cyanobacteria/microalgae for biotechnological applications, in particular for metabolic diseases. The tasks will include the extraction and fractionation techniques to produce extracts/fractions, analyses of bioactivities using phenotypic screening assays based on cells in vitro and on wildtype and transgenic zebrafish larvae in vivo. Metabolite profiling will be employed for dereplication and prioritization of bioactive fractions. Some bioactive fractions will be further characterized for their molecular modes of actions.


The candidate will also be involved in the tasks of preparing project reports and their deliverables, as well as participating in project meetings, preparing manuscripts, project proposal and other forms of communicating results. The selected candidate will also participate in supervision of students, laboratory management (orders, inventories) and maintenance of wild type and transgenic zebrafish strains.

Postdoctoral position is available in the lab of Hyun-Min Jung in the Department of Pharmacology and Regenerative Medicine at the University of Illinois at Chicago (http://mcph.uic.edu/jung/ ). Our lab focuses on understanding the cellular and molecular mechanisms of vascular development and function with a particular interest in investigating lymphatic vessels using zebrafish models and cell culture systems. We use an interdisciplinary approach that involves developmental biology, genetics/genomics, and molecular cell biology approaches to uncover key insights into lymphatic vessel formation and function. The projects the lab is currently focusing on are: 1) microRNA functions in lymphatic vessel development; 2) cell-cell crosstalk for lymphatic development; 3) endothelial response to interstitial tension; 4) new transgenic tool development.

Start Date: Positions are available now

Qualifications: The ideal candidate will have a background in genetics, molecular biology, developmental biology, or a related field. A strong interest in vascular biology is required. The position is open to individuals with a PhD or MD degree. Excellent verbal and written communication skills are required. Experience with zebrafish is preferred but not essential.

To apply: Please email to send hmjung@uic.edu a single PDF file containing:

1) cover letter (describe your motivation for pursuing postdoctoral training, why you are interested in our lab, how your background fits our research, your career goals, etc…); 2) your current CV; 3) contact information of three references (email and phone numbers).

The University of Illinois at Chicago is an affirmative action, equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status, or status as an individual with a disability.

Offers of employment by the University of Illinois may be subject to approval by the University’s Board of Trustees and are made contingent upon the candidate’s successful completion of any criminal background checks and other pre-employment assessments that may be required for the position being offered. Additional information regarding such pre-employment checks and assessments may be provided as applicable during the hiring process.

As a qualifying federal contractor, the University of Illinois System uses E-Verify to verify employment eligibility.

The University of Illinois System requires candidates selected for hire to disclose any documented finding of sexual misconduct or sexual harassment and to authorize inquiries to current and former employers regarding findings of sexual misconduct or sexual harassment. For more information, visit https://www.hr.uillinois.edu/cms/One.aspx?portalId=4292&pageId=1411899

University of Illinois faculty, staff and students are required to be fully vaccinated against COVID-19. If you are not able to receive the vaccine for medical or religious reasons, you may seek approval for an exemption in accordance with applicable University processes.

The Levin lab (http://www.drmichaellevin.org , at Tufts University near Boston) seeks people with hands-on experience with zebrafish (or any aquatic) embryo model system for projects on bioelectric controls of regeneration, brain development/repair, and cancer. A variety of position levels are available (ranging across technicians to research associates and post-docs); the ideal candidate is comfortable with: raising and scoring embryos, phenotypic analysis, microinjection, sectioning, immunohistochemistry, in situ hybridization, surgical manipulations. Additional experience with RNAseq/single cell RNAseq, bioinformatics, transgenics, larva behavior, or microscopy would be great but not required. We are actually using Xenopus, not zebrafish, but if you have that expertise in zebrafish, we'll show you the minor adjustments to be able to do frog embryo work. Please contact michael.levin@tufts.edu

New lectureships are available in the School of Biosciences, ref. UOS035198

We will consider applications in any of our research areas in the School:

https://www.sheffield.ac.uk/biosciences/research/areas

 

In the Development, Regeneration and Neurophysiology (DRN) Research Cluster, we are keen to recruit to any of the areas of developmental biology, stem cells and regeneration, and neuroscience, with a special focus on mechanobiology or the use of ‘omics technologies to understand disease and development.

https://www.sheffield.ac.uk/biosciences/research/areas/development-regeneration-and-neurophysiology

@DRN_Sheffield

 

We have superb facilities for work with zebrafish:

https://www.sheffield.ac.uk/bateson/zebrafish/information

 

The School of Biosciences has been created from a merger of the three Biology Departments: Animal and Plant Sciences, Biomedical Science and Molecular Biology and Biotechnology. The school brings together over 120 academics with a breadth and depth of excellence in multiple areas. The school will create an enhanced Learning and Teaching offering giving students opportunities to experience a greater breadth of Bioscience teaching outside their main programme, and enhanced leadership and coordination of research to better promote excellence and successful exploitation of opportunities.

 

Sheffield is a great place to live and work, close to the beautiful Peak District National Park.  

 

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

 

We are consistently ranked in the top 100 of the world’s universities, but there’s so much more to us than that. By joining the University, you will be joining award-winning teams and departments who are all working together to make the University of Sheffield a remarkable place to work.

 

More details:

https://www.jobs.ac.uk/job/CUV141/lecturer

 

Deadline: 19th December 2022

 

We are also keen to mentor applicants for Independent Research Fellowships

https://www.sheffield.ac.uk/science/research/fellowships

 

Informal enquiries

For informal enquiries about the DRN research cluster and zebrafish facilities, contact Professor Tanya Whitfield (t.whitfield@sheffield.ac.uk)

 

For informal enquiries about this job and the recruiting department, contact: Professor Rob Freckleton (Head of School) at r.freckleton@sheffield.ac.uk

 

For administration queries and details on the application process, contact the School of Biosciences HR Team at bioscienceshradmin@sheffield.ac.uk

Senior Research Scientist opportunities are immediately available within the Advanced Center for Translational Genetic Medicine (ACT-GeM) within the Stanley Manne Children’s Research Institute. The lab’s vision is to understand rare pediatric genetic disease and Senior Scientists will be considered for leadership roles on a range of interdisciplinary projects with readily available funding. The ideal candidates will be accomplished, highly motivated, and creative scientists with interests in at least one of the three following areas:

  1. understanding the architecture of human genetic disease;

2. investigating the mechanisms underlying disease processes; and

3. identification of novel therapeutic paradigms for inherited disorders.

Additionally, candidates will have the opportunity to investigate unique pediatric cohorts; use cell-based, zebrafish, or mouse models; and employ cutting-edge molecular and imaging technologies in a state-of-the-art facility. APPLICATION LINK: https://luriechildrens.wd1.myworkdayjobs.com/en-US/externalportal/details/Research-Scientist-in-the-lab-of-Erica-Davis--PhD_JR2022-1300?q=JR2022-1300

Research Technologist opportunities are immediately available at the Advanced Center for Translational Genetic Medicine (ACT-GeM) within the Stanley Manne Children’s Research Institute. The lab’s vision is to understand rare pediatric genetic disease and the Research Technologist will provide technical support roles on multiple interdisciplinary projects with readily available funding. Technologies include human exome sequencing; in vitro cell culture; zebrafish or mouse animal models; and cutting-edge molecular and imaging technologies in a state-of-the-art facility. APPLICATION LINK: https://luriechildrens.wd1.myworkdayjobs.com/en-US/externalportal/details/Research-Technologist-II_JR2022-743?q=JR2022-743

A talented postdoctoral research associate is needed to join Qatar University Biomedical Research Center (BRC), Zebrafish Facility, to work in the research team of Assoc. Prof. Huseyin Yalcin, head of the Zebrafish Facility at the center. BRC Zebrafish facility was established in 2016, and since then has been conducting multiple projects in the fields of genetics, cardiovascular disease, cancer, diabetes, neurological disorders and toxicology. Facility is very active in local and international collaborations, which resulted in more than 50 high quality publications. Facility is currently expanding with new husbandry systems, new Zebrafish lines as well as research fields. The Post-Doc research associate is expected to actively engage in these activities. Main objective for this position is adaptation of novel Zebrafish Techniques in the center, such as Crispr, Morpholino, and Xenograft. The candidate is expected to apply these techniques to ongoing and new studies and train other researchers in the facility in these techniques. The project is for 2 years. Qatar University is gradually rising in the world university rankings and is currently ranked 208th worldwide and 2nd in the Arab world in QS rankings.

Qualifications and skills: : Applicants must hold a Ph.D. from a reputable institution in Biomedical Science, Biomedical Engineering, Health Science, or a related field with experience in the following areas:

  • Zebrafish Cardiovascular research experience,

  • Having recognized scholarly output in reputable journals in the field,

  • Genetic techniques in Zebrafish such as Crispr-Cas9 and Morpholino,

  • Microscopic (fluorescent/confocal) imaging of Zebrafish,

  • Molecular biology assays and DNA/RNA sequencing,

  • Knowledge and some experience on handling zebrafish embryo/adult,

  • Knowledge and some experience about Zebrafish husbandry systems,

  • Preferred: Zebrafish Cancer, Diabetes, Toxicology, Neurological Disorders research experience

  • Preferred: Novel Zebrafish techniques experience, such as Xenograft

  • Preferred: Zebrafish exercise and stimulation assays, embryo/adult motility systems

  • Preferred: Prior Post-Doc experience

Job Duties:

  • Develop an excellent research with high integrity

  • Generate quality outcomes and peer reviewed publications

  • Establish new research protocols and procedures.

  • Responsible for laboratory operations.

  • Act as a mentor for QU junior researchers and graduate students

  • Organize training sessions and workshops

  • Teach at selected graduate level courses at the university as guest lecturer

Deadline and Benefits

  • Deadline for submitting an application is December 17, 2022 for 24 months duration starting in early 2023. A very competitive tax-free salary plus competitive benefits according to Qatar University HR policy.

How to apply

  • For informal inquiries, please send your CV to Prof. Huseyin Yalcin at hyalcin@qu.edu.qa

  • Please apply and submit the required documents through IGrantsExtent

https://www.conftool.net/igrantsExtent / Required Documents

  • Cover Letter and CV

  • Copy of Master and PhD degrees

  • Copy of Masters and PhD transcripts

  • Copy of PhD Thesis

  • 2 reference letters

The selection committee will review all the applications as soon possible after the application deadline. All the candidates will be informed about the result as soon as a decision has been made. The selected candidates will be contacted for the next steps in the selection process

http://www.qu.edu.qa/

https://brc.qu.edu.qa/research/brc

https://www.dryalcinlab.com/

https://scholar.google.com/citations?user=QtMeO8wAAAAJ&hl=en

**** Job Title: Postdoctoral Associate – Davis Lab - Chicago, IL Ann and Robert H. Lurie Children’s Hospital Stanley Manne Children’s Research Institute Advanced Center for Translational and Genetic Medicine (ACT-GeM)
PI: Erica Davis, Ph.D. Website: https://www.luriechildrens.org/act-gem Postdoctoral Associate opportunities are available within the Advanced Center for Translational and Genetic Medicine (ACT-GeM) within the Stanley Manne Children’s Research Institute. The lab’s three-point vision is to:

  1. understand the architecture of rare pediatric genetic disease,

  2. investigate the cellular mechanisms underlying disease processes, and

  3. identify novel therapeutic paradigms for inherited disorders.

Additionally, candidates will have the opportunity to investigate unique pediatric cohorts; use cell-based, zebrafish, or mouse models; and employ cutting-edge molecular and imaging technologies in a state-of-the-art facility (https://www.feinberg.northwestern.edu/sites/simpson-querrey/ ).

Job Description:

  • Work with research animals including mouse or zebrafish manipulation, and analyze data generated with such models

  • Carry out phenotypic and genotypic screening of mutant and transgenic lines.

  • Perform basic molecular biology manipulations such as DNA/RNA/protein purification and quantification, expression vector construction, morpholino injection and CRISPR/Cas9 gene editing.

  • Express mutant proteins in vitro to examine effects such as protein stability, cell/nuclear morphology and the cell cycle.

  • Perform embryo/cell imaging experiments including fixed and live-cell confocal microscopy.

  • Analyze human genetic variants for their effects on specific protein domains and cellular functions.

  • Interact with a team of trainees, technical staff, and faculty to optimize laboratory techniques and oversee the day-to-day management of multiple projects, performing advanced experimental design, optimization and interpretation.

  • Perform other duties as assigned, including assistance with posters, manuscripts and grant proposals.

Required Knowledge/Skills/Abilities:

A funded postdoctoral position is available for immediate incorporation in the Cifuentes laboratory at Boston University School of Medicine. We are looking for a highly motivated candidate excited to address fundamental questions of RNA regulation in vertebrate systems.

THE PROJECT: The available project capitalizes in a novel method developed in the Cifuentes lab to measure quantitatively protein-RNA interactions in vivo. The goal of the project is to study RNA-binding protein functions during vertebrate development. To address this goal, the lab combines high-throughput genetic, genomic, and proteomic approaches applied to zebrafish and iPSC as primary model systems.

THE LAB: We are located in a new state-of-the art lab facility at Boston University Chobanian & Avedisian School of Medicine in the highly collaborative Department of Biochemistry, with close access to scientific core facilities and immersed in the lively city of Boston, MA. We will provide to the successful candidate a stable environment and the training in experimental design, grant writing, and mentoring necessary to progress into an independent research career in academia or industry.

THE CANDIDATE: Candidates should have a Ph.D., M.D., or equivalent degree and at least a first author publication. Strong experience in molecular biology is required and knowledge of computational biology will be a plus, but even more important, is their motivation to learn and adapt to scientific challenges and become positive members of the lab.

TO APPLY: To apply please send a cover letter stating your research interests and accomplishments, CV, and contact information for three references to cifulab@bu.edu. We will review the applications until the position is filled. The position is funded for at least three years, contingent on performance. You can find additional information and our recent publications at http://www.cifulab.com