The Department for Sensory and Sensorimotor Systems of the Max-Planck-Institute for Biological Cybernetics studies the processing of sensory information (visual, auditory, tactile, olfactory) in the brain and the use of this information for directing body movements and making cognitive decisions. The research is highly interdisciplinary, and uses theoretical and experimental approaches in humans and zebra fish. Our methodologies include visual psychophysics, eye tracking, fMRI, EEG, TMS in humans and behavioral essays, calcium imaging in fish. For more information, please visit the department website: http://www.lizhaoping.org
We are currently looking for a highly skilled and motivated
Postdoctoral Fellow in Zebrafish Neuroscience (m/f/d) 100%
to join us at the earliest possible opportunity.
Responsibilities:
Conduct and participate in research activities such as study design, laboratory equipment set up, data collection, data analysis, writing reports and papers, and presenting at scientific conferences.
Assist the fish lab team and participate in routine laboratory operations, such as planning and preparations for experiments, lab maintenance and procedures.
Coordinate with the PI and other team members for project planning, and in supervision of student projects or teaching assistance for university courses in our field.
Requirements:
Ph.D. in neuroscience, biology, computer science, physics or a related natural science or engineering field.
Publications in peer-reviewed journals.
Skilled in MATLAB or Python programming for experiments, experimental data taking, data analysis.
Highly skilled in behavioral and systems neuroscience methods, especially two-photon or light sheet microscopy.
Experience in zebra fish behavioral experiments and husbandry is highly desired.
Strong command of English; knowledge of German is a plus.
We offer:
We offer highly interesting, challenging and varied tasks; you will work closely and collaboratively with scientists, students, programmers, administrative staff, and central IT and mechanical/electronic workshop support to help achieve the scientific goals of the department. A dedicated team awaits you in an international environment with regular opportunities for further education and training. The salary is paid in accordance with the collective agreement for the public sector (TVöD Bund), based on qualification and experience and will include social security benefits and additional fringe benefits in accordance with public service provisions. This position is initially limited to two years, with the possibility of extensions.
The Max Planck Society seeks to employ more handicapped people and strongly encourages them to apply. Furthermore, we actively support the compatibility of work and family life. The Max Planck Society also seeks to increase the number of women in leadership positions and strongly encourages qualified women to apply. The Max Planck Society strives for gender equality and diversity.
Your application:
The position is available immediately and will be open until filled. Preference will be given to applications received by November 30, 2021. We look forward to receiving your application that includes a cover letter, your curriculum vitae, relevant certificates, and three names and contacts for reference letters) electronically only through our job portal (https://jobs.tue.mpg.de/jobs/151 .
Informal inquiries can be addressed to jobs.li@tuebingen.mpg.de. Please note that incomplete applications will not be considered
The Department for Sensory and Sensorimotor Systems of the Max-Planck-Institute for Biological Cybernetics studies the processing of sensory information (visual, auditory, tactile, olfactory) in the brain and the use of this information for directing body movements and making cognitive decisions. The research is highly interdisciplinary, and uses theoretical and experimental approaches in humans and zebra fish. Our methodologies include visual psychophysics, eye tracking, fMRI, EEG, TMS in humans and behavioral essays, calcium imaging in fish. For more information, please visit the department website: http://www.lizhaoping.org
We are currently looking for a highly skilled and motivated student to join our group at the earliest possible opportunity.
Ph.D. position in Zebrafish Neuroscience (m/f/d) 65%
Responsibilities:
Conduct and participate in research activities such as study design, laboratory equipment set up, data collection, data analysis, writing reports and papers, and presenting at scientific conferences.
Assist the fish lab team and participate in routine laboratory operations, such as planning and preparations for experiments, lab maintenance and procedures.
Participate as a teaching assistant for university courses in our field.
Requirements:
Master’s degree in neuroscience, psychology, computer science, physics or a related natural science or engineering field.
Skilled in MATLAB or Python programming for experiments, experimental data taking, data analysis, and report writing or manuscript preparation.
Experience in (or ability to quickly learn) techniques of zebra fish behavior and imaging is highly desirable (required).
Strong command of English; knowledge of German is a plus.
We offer:
We offer highly interesting, challenging and varied tasks; you will work closely and collaboratively with scientists, students, programmers, administrative staff, and central IT and mechanical/electronic workshop support to help achieve the scientific goals of the department. A dedicated team awaits you in an international environment with regular opportunities for further education and training. The salary is paid in accordance with the collective agreement for the public sector (TVöD Bund), based on qualification and experience and will include social security benefits and additional fringe benefits in accordance with public service provisions. This position is for three years.
The Max Planck Society seeks to employ more handicapped people and strongly encourages them to apply. Furthermore, we actively support the compatibility of work and family life. The Max Planck Society also seeks to increase the number of women in leadership positions and strongly encourages qualified women to apply. The Max Planck Society strives for gender equality and diversity.
Your application:
The position is available immediately and will be open until filled. Preference will be given to applications received by November 30, 2021. We look forward to receiving your application that includes a cover letter, your curriculum vitae, relevant certificates, and three names and contacts for reference letters) electronically only through our job portal (https://jobs.tue.mpg.de/jobs/150).
Informal inquiries can be addressed to jobs.li@tuebingen.mpg.de. Please note that incomplete applications will not be considered
Rutgers, The State University of New Jersey, is seeking a Laboratory Technician for the Human Genetics Institute of NJ – Nakamura lab (Department of Genetics) and Copeland lab (Department of Biochemistry and Molecular Biology) .
This is a shared position by the two labs to maintain zebrafish facilities and conduct basic experiments of zebafish genetics. Nakamura lab reveals evolutionary and developmental mechanisms of the fish-to-tetrapod transition combining functional genomics, developmental biology, and comparative anatomy (website; http://nakamuralab.com/ . Copeland lab seeks to understand redox biology during development with an emphasis on the role of the essential trace element selenium. Due to the Covid19 , we strictly follow the state and university guidelines, including wearing masks and social distancing on the campus.
Among the key duties of this position are the following:
Under the immediate guidance and direction of a senior technician or other supervisor, provides routine technical support relative to scientific research work or projects of a laboratory and/or teaching program.
Collects and completes basic preparation of samples and specimens.
Performs standard and repetitive physical, chemical, and biological tests on materials, substances, and/or living subjects.
Prepares media, substances, solutions, and reagents and performs related duties as required.
Please see the job posting page; https://jobs.rutgers.edu/postings/142323
Any questions regarding to this position should be directed to Tetsuya Nakamura (nakamura@dls.rutgers.edu) or Paul Copeland (copelapr@rwjms.rutgers.edu).
Postdoctoral position to study zebrafish embryogenesis
A postdoctoral position is available at the University of Pittsburgh to study zebrafish embryogenesis in the following two research interests.
Topic 1: Cell adhesions for tissue morphogenesis
Tissue morphogenesis depends on cellular reorganization, which requires plastic cell adhesions at specific cell membrane regions and along distinct cell orientations. Previously, we discovered that N-cadherin-mediated apical-apical adhesion is required to establish the mirror symmetry of zebrafish neural rod (Guo, et al. 2018), and that Crb-mediated parallel adhesions are required to pattern cone mosaics in the retina (Zou, et al. 2012). How cell adhesions regulate the formation of tissues of various distinct architectures is a research interest that we want to pursue.
We have two research projects to study orientational cell adhesions in zebrafish: (1) N-cadherin-mediated cell adhesions for the formation and maintenance of the notochord and the intervertebral discs (IVDs). The tandem aligned cellular rod of the notochord changes into the 3D cellular network of the nucleus pulposus of the IVDs. IVDs often degenerate to cause low back pain. (2) Regulation of specific synaptic adhesions between photoreceptors and downstream neurons. We are interested in the molecular mechanisms that govern the development of distinct morphologies of the synaptic terminals of rod and cone photoreceptors in the zebrafish retina.
Topic 2: Transcriptional regulation of polarity genes
Cell-type-specific expression of genes is regulated by both cis- and trans-regulatory elements. The expression regulation of most genes is still unknown. A few years ago, we discovered a family of rainbow enhancers that are required for ponli and crb2b polarity genes’ restrictive expression in zebrafish red, green, and blue cone photoreceptors (RGB cones) (Fang, et al. 2017). This discovery of rainbow enhancers opens new opportunities to study gene expression regulation.
We have two research projects to study gene expression regulation: (1) Identify transcription factors that interact with rainbow enhancers. (2) Identify the enhancers of other polarity genes.
Fang W., Guo C., Wei X. (2017) Rainbow Enhancers Regulate Restrictive Transcription in Teleost Green, Red, and Blue Cones. Journal of Neuroscience. 37(11):2834-2848. A cover story .
Guo C., Zou J., Wen Y., Fang W., Stolz DB., Sun M., Wei X. (2018) Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation. iScience. 3:63-85. A cover story .
Zou J., Wang X., and Wei X. (2012) Crb apical polarity proteins maintain zebrafish retinal cone mosaics via intercellular binding of their extracellular domains. Developmental Cell. 22, 1261–1274.
We are looking for an independent, prudent, and self-motivated candidate to work on projects related to one or both of the above-mentioned research areas. Candidates should have a Ph.D. in developmental biology, genetics, molecular biology, cell biology, or biochemistry. We look forward to discussing with candidates about their research interests and career goals. Please send a cover letter, CV, research interests, and a list of references to Dr. Xiangyun Wei at the following address:
Xiangyun Wei, Ph.D.
Associate Professor
Dept. of Ophthalmology, Dept. of Developmental Biology
University of Pittsburgh School of Medicine
Pennsylvania, United States
Email: weix@upmc.edu
As part of a continuing campaign to grow and enhance the Department of Biology at the University of Kentucky (https://bio.as.uky.edu/ ) in Lexington, KY, we seek to hire two tenure-track Assistant Professors. We aim to expand research in the following areas: (1) neurobiology and (2) biology of environmental change. We are also interested in areas of biology that enhance or complement our department’s research portfolio. We welcome applicants seeking to build research programs that use any combination of empirical, computational, and theoretical approaches. Moreover, we encourage applications from individuals who will contribute to our efforts to build a diverse and inclusive department.
The Department of Biology is a highly collaborative environment with strengths in evolutionary genetics and genomics, phylogenetics and macroecology, evolutionary and behavioral ecology, neuroendocrinology and neurophysiology, biological clocks and sleep, and regenerative, developmental and stem cell biology. Biology faculty and trainee research use a diverse array of biological systems (e.g., insects, lampreys, zebrafish, birds, salamanders, rodents, primates, microbes, planaria, snakes, and vascular and non-vascular plants) and mathematical and computational tools. Members of the department collaborate with life science faculty in the Colleges of Medicine, Pharmacy, Engineering, Agriculture, and Arts & Sciences, the Markey Cancer Center, the Sanders Brown Center on Aging, and the Center for Clinical and Translational Science.
Applicants for both positions must have a Ph.D. or equivalent degree with postdoctoral experience (minimum 6 months) demonstrating excellence in their field. Evidence of an ability to obtain extramural grant support and/or some teaching experience is encouraged. Responsibilities for the successful candidates include: (1) establishment of an independent research program that is supported by awards from extramural agencies; (2) contribution to the teaching mission of the undergraduate program; (3) teaching and mentoring of graduate students and postdoctoral fellows; and (4) service for the department, university, and profession. Competitive start-up funds and renovated laboratory space will be provided.
Applicants should submit the following: 1) cover letter, 2) curriculum vitae, 3) description of the prospective research program (2 to 3 pages; upload as Specific Request 1), 4) one-page description of teaching interests (upload as Specific Request 2), and 5) statement on inclusivity (upload as Specific Request 3). As a college and university, we are strongly committed to creating an inclusive and effective teaching, learning, and working environment for all. In one to two pages, applicants should reflect on their commitments, approaches, and insights related to inclusion, diversity, and equity. In addition, please provide the names and contact information for three references when prompted in the academic profile. This information may be utilized to solicit recommendation letters from your references within the employment system.
Questions about the department and/or these searches should be addressed to Dr. David Weisrock, Chair, Department of Biology, University of Kentucky, email: david.weisrock@uky.edu.
Review of applications will begin immediately and continue until the position is filled. Applications received before October 15, 2021 are assured full consideration.
The Poulain lab (++ www.poulainlab.org) at the University of South Carolina is searching for a talented and motivated postdoc! Our NIH-funded research program focuses on the cellular and molecular mechanisms underlying neural circuit formation and maintenance in vivo. We use the zebrafish visual system as a model and a unique combination of genetic, embryological and high resolution live imaging approaches to test the role of selective axon degeneration in circuit wiring and the contribution of trans-axonal signaling to retinotopic map formation and maintenance. Candidates should hold a PhD in neurobiology, cell and molecular biology, or related fields, and have a strong interest in neural development. Significant experience in molecular biology, genetics and fluorescence imaging approaches is required. Experience with zebrafish is desired but not mandatory. Applicants from underrepresented groups in sciences are highly encouraged to apply. Interested candidates should email their resume/CV, the names and contact information of at least three references, and a cover letter explaining their interest to fpoulain@mailbox.sc.edu (please title the email subject as “postdoc position”).
NIH-funded postdoctoral positions are open in the laboratory of Dr. Jeff Mumm at the Johns Hopkins University in Baltimore Maryland, USA. Successful candidates will lead a project to create novel resources for dissecting cell subtype function and enabling investigations of cellular regeneration in the nervous system. The project will require mastery of state-of-the-art molecular, cellular, and imaging techniques, including CRISPR/Cas-based knock in gene targeting. Preferred candidates will have prior experience with targeted transgenesis. Project leaders will also be given the opportunity to participate in ongoing related research in the lab and to develop their own independent research program.
Interested individuals should send a cover letter, CV, and the names of three references to Dr. Mumm: jmumm3@jhmi.edu.
JHU promotes intellectual interaction, provides state-of-the-art resources, and fosters diversity in our workforce.
Job Title: Aquatics Technician 1
Department: Ctr for Comparative Medicine
Salary/Grade: NEX/10
Job Summary:
Specializes in the care of laboratory zebrafish. Performs daily zebrafish husbandry activities including water quality assessment, recirculating system maintenance, and tank washing. All actions are completed by strictly & consistently following applicable CCM SOPs including safety procedures & guidelines. Reports any suspected or actual deviations to SOPs or non-routine situations immediately to Group Leader or their designee. Arrives, leaves & takes breaks at work as scheduled. Strictly adheres to CCM attendance policy.
Please Note: Must be able to negotiate up to a 65 lb force (push/pull) on an occasional basis. Lifting is limited to 50 lbs occasionally and 25 lbs frequently. Must be able to work a shift schedule that includes working both Saturdays and Sundays, possibly a staggered work schedule, occasional overtime, and holidays as required. Must successfully maintain physical condition that will assure efficient performance of tasks, including successful completion of physical examination. This position requires the individual to be available to work on both the Chicago and Evanston campuses as coverage needs dictate.
Must be enrolled in the university’s occupational health program which entails filling out a health questionnaire. The health questionnaire is submitted to the university’s occupational health provider for review. Must be willing to undergo job related background check.
Specific Responsibilities:
· Cleans & sterilizes tanks, equipment, supplies, rooms (primary and secondary enclosures), etc.
· Prepares refuse for disposal.
· Observes tanks daily for cleanliness, appropriate water supply, stocking density, and tank assembly.
· Observes recirculating systems daily for appropriate function.
· Changes tanks, lids, and water supply hoses.
· Feeds zebrafish according to their prescribed diets.
· Observes zebrafish regularly during the day, noting, reporting, and removing any dead fish or fish with variances in or deviation from normal health or behavior, including obvious deviations in swimming behavior, skin conditions, enlarged abdomens etc.
· Notifies veterinary staff and researchers of fish with health issues.
· Observes, documents, & reports changes in environmental parameters (i.e., water & room temperature, room humidity & lighting, water conductivity, water pH etc.).
· Conducts census counts.
· Euthanizes fish according to CCM policy.
· Complies with aquatics facility entry order, PPE requirements, and other biosecurity policy as directed.
· Assists in organizing feed and supplies.
· Completes facility caretaking check-lists, logs & documentation accurately & within appropriate time-frames.
· Notifies supervisor and/or management of malfunctioning equipment; may document problem.
· May participate in the training of new Aquatics Technicians & or investigator staff. Attends CCM sponsored training sessions, OJT's, species-specific training sessions, etc. Cross trains in animal caretaking duties of all currently housed species.
Miscellaneous
· Performs other duties as assigned.
Minimum Qualifications:
· A high school diploma or its equivalent is required along with a minimum of 2 years of experience as an animal care or research technician working with aquatic species.
Minimum Competencies: (Skills, knowledge, and abilities)
· Aquatic animal care
· Organization and multitasking
· Efficiency/dependability
· Must be able to type and have working knowledge of spreadsheet, word processing, database and e-mail software
Preferred Qualifications:
· BS in aquaculture, fisheries, or related field.
· ALAT certification.
· Prior experience working with zebrafish.
· Basic knowledge of water quality assessment.
· Experience with maintenance of recirculating aquaculture systems.
Preferred Competencies: (Skills, knowledge, and abilities)
· Customer focus
Please visit the Northwestern Careers website to apply.
The Özbudak Lab (https://www.cincinnatichildrens.org/bio/o/ertugrul-ozbudak ) is looking for a postdoctoral fellow interested in combining interdisciplinary approaches to discover systems-level mechanisms governing spatiotemporal pattern formation during embryonic development.
Embryos develop spatiotemporal patterns by encoding and interpreting biological signals in real time. Despite unavoidable fluctuations in gene expression, embryonic development is robust and reproducible, which necessitates several mechanisms buffering stochastic gene expression. A striking example of robust spatiotemporal patterning is the rhythmic segmentation of somites, which are precursors of the vertebral column. Segmentation of somites is controlled by: 1) oscillatory expression of Hes/Her gene family, known as the vertebrate segmentation clock, 2) short-distance Notch signaling, 3) long-distance Fgf and Wnt signaling gradients, and 4) a network of transcription factors integrating outputs of the segmentation clock and the signaling pathways. Errors in this regulatory cascade result in various birth defects, including congenital scoliosis. We combine single-cell microscopy measurements, time-resolved perturbation experiments, biophysical modeling and computational simulations to decipher the mechanism underlying robust spatiotemporal pattern formation and cell fate determination.
Relevant publications: Nature 2021 589:431-436; Cell Reports 2018 24:66-78; Cell Reports 2018 23:2175-2185.
Interested candidate must have a PhD and have a strong record of accomplishments and experience in:
1- Genetics, developmental biology, microscopy, and image analysis; OR
2- Mathematical and computational modeling, or theoretical physics
We are looking for a colleague who is highly motivated and independent. Please send a cover letter detailing your past research accomplishments and future research goals, and your CV by email to:
Ertugrul M. Ozbudak
Laboratory of Systems Developmental Biology
Division of Developmental Biology
Cincinnati Children's Hospital Medical Center
University of Cincinnati College of Medicine
Email: Ertugrul.Ozbudak@cchmc.org
The laboratory of Prof. Dan Larhammar is recruiting a researcher to investigate the roles of candidate memory genes using zebrafish behavioural paradigms for spatial and social memory. The work also includes evolutionary comparisons of memory genes and proteins by analysis of sequences, gene duplications and chromosomal synteny. The anatomical distribution of the memory proteins in the zebrafish brain will be mapped by in situ hybridization, immunohistochemistry and reporter constructs in genetically modified zebrafish.
The project will involve collaboration with other research teams with expertise in spatial memory paradigms in our department and social memory paradigms at University of Gothenburg. Together the teams cover a broad range of expertise in molecular biology, genetics, evolutionary biology, ecology and behaviour.
Requirements: To qualify for an employment as a postdoctor you must have a PhD degree or a foreign degree equivalent to a PhD degree and expertise in studies of fish behaviour, ideally also bioinformatics for evolutionary studies based on comparisons of sequence and synteny, and anatomical studies using in situ hybridization. The PhD degree must have been obtained no more than three years prior to the application deadline. The three year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc. Good English language skills and good ability to work in a team are required. The applicant is required to have FELASA function A certificate (directive 2010/63/ EU, article 23 and 24) for work with animals and experience of work with fish.
Learning and long-term memory are intriguing and fascinating properties of vertebrate brains. Numerous proteins have been found to be involved in these processes in mouse and rat. Our evolutionary analyses have shown that virtually all of these proteins arose before the origin of jawed vertebrates. We are therefore studying their importance in learning and long-term memory in zebrafish, a widely used model species in biomedical research. We use CRISPR/Cas9 to inactivate genes and to make reporter constructs. Such modified zebrafish have now been generated for protein kinases implicated in long-term memory. Behavioural studies of spatial and social memory will be carried out to compare the genetically modified zebrafish with wildtype animals. The project also includes the use bioinformatics to deduce evolutionary relationships of memory genes using both sequence-based phylogeny and comparison of synteny.
As memory mechanisms have so far mostly been investigated in mouse and rat, we find it important to expand the evolutionary perspective by studying more distant relatives of mammals, in our case the zebrafish. If memory mechanisms turn out to be similar in zebrafish and the two rodents, this will provide a much firmer ground for extrapolation to humans. On the other hand, if the functional roles differ between zebrafish and rodents, we cannot be sure if the rodent situation will apply to humans. Central proteins in the memory machinery are different types of glutamate receptors, especially AMPA- receptors and NMDA-receptors, and various proteins that regulate these receptors. We are initially focusing on protein kinases that regulate AMPA-receptor turnover in memory synapses.
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 45,000 students, more than 7,000 employees and a turnover of around SEK 7 billion.
The research performed at the department of Neuroscience covers the normal function of the nervous system, its development as well as how function of the nervous system is altered following injury and in disease, and how to improve treatment of patients with these disorders. In addition, studies are carried out on genetic and acquired factors that can give rise to or contribute to nervous system disorders and underlie personality disorders (e.g. drug abuse, criminality).
The application should include:
A short letter with a description of your research interests and how you could contribute to the project. - CV with complete publication list.
Copy of PhD certificate.
Copy of FELASA function A certificate (directive 2010/63/EU, article 23 and 24).
Contact information for at least two references (email and phone number).
Salary: Individual salary.
Starting date: 01-10-2021 or as otherwise agreed.
Type of employment: Temporary position according to central collective agreement.
Scope of employment: 100 %.
For further information about the position please contact: Dan Larhammar, dan.larhammar@neuro. http://uu.se .
Please submit your application by 16 September 2021, UFV-PA 2021/3233.
Submit your application through Uppsala University's recruitment system.
Link to advertisement: http://uu.varbi.com/what:job/jobID:425923/
Page Title
När du har kontakt med oss på Uppsala universitet med e-post så innebär det att vi behandlar dina personuppgifter. För att läsa mer om hur vi gör det kan du läsa här: http://www.uu.se/om-uu/dataskydd-personuppgifter/
E-mailing Uppsala University means that we will process your personal data. For more information on how this is performed, please read here: http://www.uu.se/en/about-uu/data-protection-policy
The laboratory of Prof. Dan Larhammar is recruiting a PhD for a postdoctoral stipend or employment to investigate the roles of candidate memory genes using zebrafish behavioural paradigms for spatial and social memory. The work also includes evolutionary comparisons of memory genes and proteins by analysis of sequences, gene duplications and chromosomal synteny. The anatomical distribution of the memory proteins in the zebrafish brain will be mapped by in situ hybridization, immunohistochemistry and reporter constructs in genetically modified zebrafish.
The project will involve collaboration with other research teams with expertise in spatial memory paradigms in our department and social memory paradigms at University of Gothenburg. Together the teams cover a broad range of expertise in molecular biology, genetics, evolutionary biology, ecology and behaviour.
Requirements: To qualify for an employment as a postdoctor you must have a PhD degree or a foreign degree equivalent to a PhD degree and expertise in studies of fish behaviour, ideally also bioinformatics for evolutionary studies based on comparisons of sequence and synteny, and anatomical studies using in situ hybridization. The PhD degree must have been obtained no more than three years prior to the application deadline. The three year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc. Good English language skills and good ability to work in a team are required. The applicant is required to have FELASA function A certificate (directive 2010/63/ EU, article 23 and 24) for work with animals and experience of work with fish.
Learning and long-term memory are intriguing and fascinating properties of vertebrate brains. Numerous proteins have been found to be involved in these processes in mouse and rat. Our evolutionary analyses have shown that virtually all of these proteins arose before the origin of jawed vertebrates. We are therefore studying their importance in learning and long-term memory in zebrafish, a widely used model species in biomedical research. We use CRISPR/Cas9 to inactivate genes and to make reporter constructs. Such modified zebrafish have now been generated for protein kinases implicated in long-term memory. Behavioural studies of spatial and social memory will be carried out to compare the genetically modified zebrafish with wildtype animals. The project also includes the use bioinformatics to deduce evolutionary relationships of memory genes using both sequence-based phylogeny and comparison of synteny.
As memory mechanisms have so far mostly been investigated in mouse and rat, we find it important to expand the evolutionary perspective by studying more distant relatives of mammals, in our case the zebrafish. If memory mechanisms turn out to be similar in zebrafish and the two rodents, this will provide a much firmer ground for extrapolation to humans. On the other hand, if the functional roles differ between zebrafish and rodents, we cannot be sure if the rodent situation will apply to humans. Central proteins in the memory machinery are different types of glutamate receptors, especially AMPA- receptors and NMDA-receptors, and various proteins that regulate these receptors. We are initially focusing on protein kinases that regulate AMPA-receptor turnover in memory synapses.
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 45,000 students, more than 7,000 employees and a turnover of around SEK 7 billion.
The research performed at the department of Neuroscience covers the normal function of the nervous system, its development as well as how function of the nervous system is altered following injury and in disease, and how to improve treatment of patients with these disorders. In addition, studies are carried out on genetic and acquired factors that can give rise to or contribute to nervous system disorders and underlie personality disorders (e.g. drug abuse, criminality). The application should include:
A short letter with a description of your research interests and how you could contribute to the project. - CV with complete publication list.
Copy of PhD certificate.
Copy of FELASA function A certificate (directive 2010/63/EU, article 23 and 24).
Contact information for at least two references (email and phone number).
Salary: Individual salary.
Starting date: 01-10-2021 or as otherwise agreed.
Type of employment: Temporary position according to central collective agreement.
Scope of employment: 100 %.
For further information about the position please contact: Dan Larhammar, dan.larhammar@neuro. http://uu.se .
Please submit your application by 16 September 2021, UFV-PA 2021/3205.
Submit your application through Uppsala University's recruitment system.
Link to advertisement: http://uu.varbi.com/what:job/jobID:425488/
Page Title
När du har kontakt med oss på Uppsala universitet med e-post så innebär det att vi behandlar dina personuppgifter. För att läsa mer om hur vi gör det kan du läsa här: http://www.uu.se/om-uu/dataskydd-personuppgifter/
E-mailing Uppsala University means that we will process your personal data. For more information on how this is performed, please read here: http://www.uu.se/en/about-uu/data-protection-policy
The Department of Biology at the University of New Brunswick in Fredericton invites applications for a tenure-track position at the rank of Assistant Professor to begin July 1, 2022or as negotiated. We seek candidates who will develop an innovative research program investigating cellular and molecular mechanisms in established model or novel systems using modern molecular genetic approaches.
We welcome applications from candidates who can build research collaborations within and outside of the Department. Research in the Department of Biology ranges from molecular biology to ecosystems, using computational, lab and field-based approaches. Candidates whose research complements existing expertise or develops a new area of research with value to the Department are desired.
The candidate is expected to develop an externally funded research program in molecular genetics. Opportunities for funding exist through the New Brunswick Health Research Foundation, the New Brunswick Innovation Foundation and the Atlantic Canada Opportunities Agency, as well as national opportunities available through CIHR, NSERC, MITACS, CFI and other federal funding sources. Qualifications: The successful candidate must hold a PhD in a relevant discipline and have postdoctoral experience. A proven track record in publishing significant research findings in molecular genetics is essential. Candidates should also demonstrate a record of, or potential for, excellence in teaching at the undergraduate and graduate levels.
Applicants should submit a single PDF containing all application materials. Please include a cover letter, a curriculum vitae, research and teaching statements, copies of three of your most significant publications (each with a 300-word-maximum explanation of your contribution to the work and why it is significant), and names and contact information for three referees willing to provide letters of reference. Send applications by email to: Dr. Dion Durnford, Chair c/o JennaMeade at jenn.meade@unb.caindicating “Molecular Genetics” in the subject line.Short-listed candidates will be required to provide satisfactory proof-of-credentials, including appropriately certified translations of credentials into English, as applicable.
The deadline for applications is October 1st, 2021.
The University of New Brunswick is committed to employment equity and fostering diversity within our community and developing an inclusive workplace that reflects the richness of the broader community that we serve. The University welcomes and encourages applications from all qualified individuals who will help us achieve our goals, including women, visible minorities, Indigenous persons, persons with disabilities, and persons of any sexual orientation, gender identity or gender expression. Preference will be given to Canadian citizens and permanent residents of Canada. Applicants should indicate current citizenship status. This position is subject to budgetary approval
The Department of Biology at the University of New Brunswick in Fredericton invites applications for a tenure-track position at the rank of Assistant Teaching Professor to begin July 1, 2022.The primary role of the position is to teach and coordinate the first-year biology laboratory courses. We are looking for an individual who will collaborate with faculty who teach the introductory biology lecture courses to create an integrated first-year biology program for 500 students with diverse academic backgrounds.
We seek an outstanding instructor who takes an evidence-based pedagogical approach to university education. The successful candidate will review current labs and develop new ones based on the defined educational outcomes for students, in conjunction with themes taught in the introductory biology lecture courses. The candidate should be very comfortable teaching in all the major areas of biology. We seek a dynamic individual who will work with a team of teaching assistants and technicians to create a welcoming and supportive learning environment and foster student engagement.
Qualifications: The successful candidate must hold a PhD in biology. A proven track record in high-quality teaching is an asset. Experience in implementing different educational approaches or publications on pedagogical practices in university biology will be considered assets. Applicants should submit a single PDF containing all application materials. Please include a cover letter, a curriculum vitae, a teaching dossier, and a statement of teaching philosophy. Also include the names and contact information for three referees willing to provide letters of reference. Send applications by email to: Dr. Dion Durnford, Chair c/o Jenn Meade at Jenn.meade@unb.caindicating “First Year Instructor” in the subject line.Short-listed candidates will be required to provide satisfactory proof-of-credentials, including appropriately certified translations of credentials into English, as applicable.
The Deadline for applications is October 1, 2021.
The University of New Brunswick is committed to employment equity and fostering diversity within our community and developing an inclusive workplace that reflects the richness of the broader community that we serve. The University welcomes and encourages applications from all qualified individuals who will help us achieve our goals, including women, visible minorities, Aboriginal persons, persons with disabilities, and persons of any sexual orientation, gender identity or gender expression. Preference will be given to Canadian citizens and permanent residents of Canada. Applicants should indicate current citizenship status. This position is subject to budgetary approval.
Our team and line of research
Yasmine Cantaut-Belarif is a CNRS Research Associate at the Paris Brain Institute. She joined the team of Claire Wyart to investigate the role of cerebrospinal fluid during development. She showed that a conserved polymer bathing in the cavities of the brain and spinal cord, named the Reissner fiber, controls the geometry of the posterior axis in developing zebrafish embryos. Since 2020, her work aims to unravel the mechanisms by which this acellular thread influences the morphogenesis and the alignment of the body at embryonic and post-embryonic stages.
The position
We are seeking to appoint a postdoctoral researcher to join a 3-year research programme in developmental neuroscience funded by the Agence Nationale de la Recherche (ANR).
The aim of the programme is to understand how the Reissner fiber bathing in the cerebrospinal fluid shapes the geometry of the body and the alignment of the spine during post-embryonic stages. More specifically, we seek to identify the mechanisms by which this fiber is maintained over time in the brain and spinal cord cavities, (ii) to dissect the fundamental molecular and cellular pathways controlling the maintenance of this structure influencing body and spine shape. To address these questions, the candidate will combine the power of genetics and in vivo state-of-the-art imaging in zebrafish and develop approaches including gain-and-loss of function as well as structural and functional analysis of transgenic lines.
Contract & Starting date
One-year renewable contract (three years total)
Starting: January 2022 (flexible)
The environment and team spirit
The Paris Brain Institute provides a stimulating environment hosting an international and interdisciplinary community of outstanding scientists as well as cutting-edge resources and facilities. Our lab culture is to promote communication- and cooperation-based mentoring to achieve creative and rigorous research and to foster the scientific maturity and independence of our trainees!
Candidate profile
We are seeking for a motivated candidate
working with a proactive and cooperative style in a team
willing to approach tasks with structured working methods and reproducibility in mind
able to communicate in an interdisciplinary and international working environment
Required selection criteria
PhD or MD/PhD with a background in cell/developmental biology and neuroscience. Graduate students about to defend their PhD are encouraged to apply!
Significant technical expertise in imaging, cell and molecular biology. Programming (Matlab, Python) will be a plus
Previous experience in zebrafish is welcome but not required
Excellent organizational skills, self-motivation and creativity
How to apply
Interested applicants must send
a cover letter stating the research interests and motivation to join us: we want to know more about your vision of science and your work spirit!
a CV including technical skills
a list of publications highlighting the most relevant and impactful paper
2 reference letters
Contact
Dr. Yasmine Cantaut-Belarif, CNRS Research Associate
Paris Brain Institute
yasmine.belarif@icm-institute.org
Learn more about the institute and the lab
The Paris Brain Institute https://institutducerveau-icm.org/fr/team/equipe-wyart/ The Spinal Sensory Signalling lab http://wyartlab.org/
Interested in development, cell fate, neural circuits, and wiring? We received an R21 grant to examine motoneurons in zebrafish and we are seeking a postdoctoral fellow and a research assistant to work on the project. The work will focus on using single cell RNA-seq to investigate motoneuron populations in early developing zebrafish. Over the course of the project the researcher will be expected to generate new sequencing data, examine the transcriptomes (bioinformatics), generate transgenics and mutants (CRISPR), examine the phenotypes (imaging), and disseminate the work (go to conferences and write papers).
This is a collaborative project between Dr. Judith Eisen and Dr. Adam Miller, at the Institute of Neuroscience, University of Oregon (https://ion.uoregon.edu/ ). Come join a great group of scientists, a great community, and lead the charge on figuring out a new frontier for the vertebrate nervous system!
Successful candidates will have a degree of an appropriate level for the position of application (Ph.D. = PD and B.S. = RA). A published record of accomplishment appropriate to level, and good written and oral communication skills.
Preferred: Experience in model organism biology (zebrafish a plus but not required), bioinformatics and next generation sequencing experience, cloning, molecular biology of DNA/RNA/protein, microscopy, CRISPR, embryo injections, complex genetics. Level of experience in these techniques varies depending on level of applicant (PD/RA).
Required: Enthusiasm, excitement to be part of a large multi-lab project, ability to coordinate across labs, rigor, organization, excellence and drive.
Eugene, Oregon is an ideal place to work and live, and is an outdoor enthusiast’s paradise. In addition to a mild climate with access to the ocean and mountains, Eugene has affordable housing, bike-friendly streets, and a strong community feel. The University of Oregon is an Equal Opportunity/Affirmative Action Institution committed to cultural diversity and compliance with the Americans with Disabilities Act.
Interested candidates should send a curriculum vitae, bibliography, cover letter with a brief description of research experience and interests, and the names of 3 references (with phone numbers) via e-mail to eisen@uoregon.eduand acmiller@uoregon.edu.